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- NCIT_C79828 IAO_0000115 "A fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R) with potential antineoplastic activity. Cixutumumab selectively binds to membrane-bound IGF-1R, thereby preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signaling pathway. Downregulation of the PI3K/AKT survival pathway may result in the induction of cancer cell apoptosis and may decrease cancer cellular proliferation. IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by many cancer cell types, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been implicated in tumorigenesis and metastasis." @default.
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- NCIT_C79828 NCIT_NHC0 "C79828" @default.
- NCIT_C79828 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C79828 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C79828 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C79828 NCIT_P107 "Cixutumumab" @default.
- NCIT_C79828 NCIT_P108 "Cixutumumab" @default.
- NCIT_C79828 NCIT_P207 "C2703174" @default.
- NCIT_C79828 NCIT_P210 "947687-12-9" @default.
- NCIT_C79828 NCIT_P319 "2285XW22DR" @default.
- NCIT_C79828 NCIT_P322 "CTRP" @default.
- NCIT_C79828 NCIT_P322 "FDA" @default.
- NCIT_C79828 NCIT_P322 "GDC" @default.
- NCIT_C79828 NCIT_P325 "A substance being studied in the treatment of some types of cancer. It is a monoclonal antibody that is made in the laboratory and can bind to substances in the body. Cixutumumab blocks the action of a protein needed for cell growth and may kill cancer cells. It is a type of insulin-like growth factor-1 receptor (IGF-1R) inhibitor." @default.
- NCIT_C79828 NCIT_P329 "561575" @default.
- NCIT_C79828 NCIT_P330 "561575" @default.
- NCIT_C79828 NCIT_P366 "Cixutumumab" @default.
- NCIT_C79828 NCIT_P375 "Cixutumumab" @default.
- NCIT_C79828 NCIT_P399 "561575" @default.
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- NCIT_C79828 normalizedInformationContent "100" @default.
- NCIT_C79828 referenceCount "1" @default.
- NCIT_C79828 hasExactSynonym "Anti-IGF-1R Recombinant Monoclonal Antibody IMC-A12" @default.
- NCIT_C79828 hasExactSynonym "CIXUTUMUMAB" @default.
- NCIT_C79828 hasExactSynonym "Cixutumumab" @default.
- NCIT_C79828 hasExactSynonym "IMC-A12" @default.
- NCIT_C79828 hasExactSynonym "cixutumumab" @default.
- NCIT_C79828 inSubset NCIT_C116977 @default.
- NCIT_C79828 inSubset NCIT_C116978 @default.
- NCIT_C79828 inSubset NCIT_C128784 @default.
- NCIT_C79828 inSubset NCIT_C157711 @default.
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- NCIT_C79828 inSubset NCIT_C63923 @default.
- NCIT_C79828 type Class @default.
- NCIT_C79828 isDefinedBy ncit.owl @default.
- NCIT_C79828 label "Cixutumumab" @default.
- NCIT_C79828 subClassOf B5d248ba37149e66165a74b2770ca1466 @default.
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- NCIT_C79828 subClassOf NCIT_C79828 @default.