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- NCIT_C79831 IAO_0000115 "The orally bioavailable mesylate salt of masatinib, a multi-targeted protein tyrosine kinase inhibitor with potential antineoplastic activity. Masitinib selectively binds to and inhibits both the wild-type and mutated forms of the stem cell factor receptor (c-Kit; SCFR); platelet-derived growth factor receptor (PDGFR); fibroblast growth factor receptor 3 (FGFR3); and, to a lesser extent, focal adhesion kinase (FAK). As a consequence, tumor cell proliferation may be inhibited in cancer cell types that overexpress these receptor tyrosine kinases (RTKs)." @default.
- NCIT_C79831 NCIT_A32 NCIT_C1909 @default.
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- NCIT_C79831 NCIT_A7 NCIT_C26129 @default.
- NCIT_C79831 NCIT_NHC0 "C79831" @default.
- NCIT_C79831 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C79831 NCIT_P107 "Masitinib Mesylate" @default.
- NCIT_C79831 NCIT_P108 "Masitinib Mesylate" @default.
- NCIT_C79831 NCIT_P207 "C2351399" @default.
- NCIT_C79831 NCIT_P210 "1048007-93-7" @default.
- NCIT_C79831 NCIT_P319 "ZK89EG3A18" @default.
- NCIT_C79831 NCIT_P322 "CTRP" @default.
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- NCIT_C79831 NCIT_P329 "629109" @default.
- NCIT_C79831 NCIT_P330 "629109" @default.
- NCIT_C79831 NCIT_P366 "Masitinib_Mesylate" @default.
- NCIT_C79831 NCIT_P375 "Masitinib Mesylate" @default.
- NCIT_C79831 NCIT_P399 "629109" @default.
- NCIT_C79831 NCIT_R124 NCIT_C17828 @default.
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- NCIT_C79831 NCIT_R125 NCIT_C20751 @default.
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- NCIT_C79831 NCIT_R125 NCIT_C41515 @default.
- NCIT_C79831 NCIT_R125 NCIT_C51037 @default.
- NCIT_C79831 normalizedInformationContent "100" @default.
- NCIT_C79831 referenceCount "1" @default.
- NCIT_C79831 hasExactSynonym "4-[(4-Methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)benzamide Mesylate" @default.
- NCIT_C79831 hasExactSynonym "AB1010" @default.
- NCIT_C79831 hasExactSynonym "MASITINIB MESYLATE" @default.
- NCIT_C79831 hasExactSynonym "Masitinib Mesylate" @default.
- NCIT_C79831 inSubset NCIT_C116977 @default.
- NCIT_C79831 inSubset NCIT_C116978 @default.
- NCIT_C79831 inSubset NCIT_C128784 @default.
- NCIT_C79831 inSubset NCIT_C157711 @default.
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- NCIT_C79831 inSubset NCIT_C176424 @default.
- NCIT_C79831 inSubset NCIT_C177537 @default.
- NCIT_C79831 inSubset NCIT_C63923 @default.
- NCIT_C79831 type Class @default.
- NCIT_C79831 isDefinedBy ncit.owl @default.
- NCIT_C79831 label "Masitinib Mesylate" @default.
- NCIT_C79831 subClassOf B1118a8cad28a44eda0841c1aaa0848e7 @default.
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- NCIT_C79831 subClassOf NCIT_C1404 @default.
- NCIT_C79831 subClassOf NCIT_C1908 @default.
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- NCIT_C79831 subClassOf NCIT_C1967 @default.
- NCIT_C79831 subClassOf NCIT_C2189 @default.
- NCIT_C79831 subClassOf NCIT_C274 @default.
- NCIT_C79831 subClassOf NCIT_C471 @default.
- NCIT_C79831 subClassOf NCIT_C79831 @default.