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- NCIT_C79832 IAO_0000115 "A cancer vaccine consisting of a replication-defective recombinant canarypox virus [ALVAC(2)] encoding the cancer-testis antigen NY-ESO and the TRIad of COstimulatory Molecules (B7-1, ICAM-1 and LFA-3; also called TRICOM), with potential immunostimulatory and antineoplastic activities. Upon administration, ALVAC(2)/NY-ESO (M)/TRICOM vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against NY-ESO-expressing cancer cells, which may result in the inhibition of tumor cell proliferation. NY-ESO-1, a tumor associated antigen (TAA), is found in normal testis and on the surface of various tumor cells, including bladder, breast, hepatocellular, melanoma, and prostate tumor cells. TRICOM may enhance antigen presentation and activate cytotoxic T-cells. In addition, ALVAC(2) encodes the vaccinia virus (vv) E3L ad K3L genes, which may potentiate the translation of the NY-ESO and TRICOM genes." @default.
- NCIT_C79832 NCIT_NHC0 "C79832" @default.
- NCIT_C79832 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C79832 NCIT_P107 "ALVAC(2)-NY-ESO-1 (M)/TRICOM Vaccine" @default.
- NCIT_C79832 NCIT_P108 "ALVAC(2)-NY-ESO-1 (M)/TRICOM Vaccine" @default.
- NCIT_C79832 NCIT_P208 "CL388436" @default.
- NCIT_C79832 NCIT_P322 "CTRP" @default.
- NCIT_C79832 NCIT_P329 "629375" @default.
- NCIT_C79832 NCIT_P330 "629375" @default.
- NCIT_C79832 NCIT_P366 "ALVAC_2_NY-ESO-1_M_TRICOM_Vaccine" @default.
- NCIT_C79832 NCIT_P399 "629375" @default.
- NCIT_C79832 normalizedInformationContent "100" @default.
- NCIT_C79832 referenceCount "1" @default.
- NCIT_C79832 hasExactSynonym "ALVAC(2)-NY-ESO-1 (M)/TRICOM Vaccine" @default.
- NCIT_C79832 hasExactSynonym "vCP2292" @default.
- NCIT_C79832 inSubset NCIT_C116977 @default.
- NCIT_C79832 inSubset NCIT_C116978 @default.
- NCIT_C79832 inSubset NCIT_C128784 @default.
- NCIT_C79832 inSubset NCIT_C176424 @default.
- NCIT_C79832 type Class @default.
- NCIT_C79832 isDefinedBy ncit.owl @default.
- NCIT_C79832 label "ALVAC(2)-NY-ESO-1 (M)/TRICOM Vaccine" @default.
- NCIT_C79832 subClassOf NCIT_C1479 @default.
- NCIT_C79832 subClassOf NCIT_C1572 @default.
- NCIT_C79832 subClassOf NCIT_C1908 @default.
- NCIT_C79832 subClassOf NCIT_C1909 @default.
- NCIT_C79832 subClassOf NCIT_C307 @default.
- NCIT_C79832 subClassOf NCIT_C308 @default.
- NCIT_C79832 subClassOf NCIT_C79832 @default.
- NCIT_C79832 subClassOf NCIT_C923 @default.
- NCIT_C79832 subClassOf NCIT_C96404 @default.