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- NCIT_C79833 IAO_0000115 "An attenuated oncolytic vaccinia virus encoding the light-emitting fusion protein Renilla luciferase-Aequorea green fluorescent protein (RUC-GFP) with potential bioluminescent and antineoplastic activities. Upon administration, light-emitting oncolytic vaccinia virus GL-ONC1 specifically enters tumor cells due to the permeable nature of the tumor vasculature. Once inside the cell, the virus replicates, resulting in tumor cell lysis and the release of mature viral particles into the tumor microenvironment. Released viral particles may then infect and destroy neighboring tumor cells. In addition, the release of tumor-associated antigens (TAAs) by lysed tumor cells into the bloodstream may activate the immune system to mount a cytotoxic T lymphocyte (CTL) response against the tumor. The expression of RUC-GFP by this agent allows for both detection and monitoring of virally infected tumor cells in vivo and vitro with luciferase-mediated bioluminescence imaging and fluorescence imaging techniques." @default.
- NCIT_C79833 NCIT_A32 NCIT_C1909 @default.
- NCIT_C79833 NCIT_NHC0 "C79833" @default.
- NCIT_C79833 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C79833 NCIT_P107 "Olvimulogene Nanivacirepvec" @default.
- NCIT_C79833 NCIT_P108 "Olvimulogene Nanivacirepvec" @default.
- NCIT_C79833 NCIT_P208 "CL388438" @default.
- NCIT_C79833 NCIT_P210 "1473430-36-2" @default.
- NCIT_C79833 NCIT_P319 "CF19SF72O5" @default.
- NCIT_C79833 NCIT_P322 "CTRP" @default.
- NCIT_C79833 NCIT_P322 "FDA" @default.
- NCIT_C79833 NCIT_P322 "GDC" @default.
- NCIT_C79833 NCIT_P329 "629379" @default.
- NCIT_C79833 NCIT_P330 "629379" @default.
- NCIT_C79833 NCIT_P366 "Light-Emitting_Oncolytic_Vaccinia_Virus_GL-ONC1" @default.
- NCIT_C79833 NCIT_P375 "Light-Emitting Oncolytic Vaccinia Virus GL-ONC1" @default.
- NCIT_C79833 NCIT_P375 "Olvimulogene Nanivacirepvec" @default.
- NCIT_C79833 NCIT_P399 "629379" @default.
- NCIT_C79833 normalizedInformationContent "100" @default.
- NCIT_C79833 referenceCount "1" @default.
- NCIT_C79833 hasExactSynonym "GL-ONC1" @default.
- NCIT_C79833 hasExactSynonym "GLV-1h68" @default.
- NCIT_C79833 hasExactSynonym "OLVIMULOGENE NANIVACIREPVEC" @default.
- NCIT_C79833 hasExactSynonym "Olvi-Vec" @default.
- NCIT_C79833 hasExactSynonym "Olvimulogene Nanivacirepvec" @default.
- NCIT_C79833 inSubset NCIT_C116977 @default.
- NCIT_C79833 inSubset NCIT_C116978 @default.
- NCIT_C79833 inSubset NCIT_C128784 @default.
- NCIT_C79833 inSubset NCIT_C157711 @default.
- NCIT_C79833 inSubset NCIT_C157712 @default.
- NCIT_C79833 inSubset NCIT_C176424 @default.
- NCIT_C79833 inSubset NCIT_C177537 @default.
- NCIT_C79833 inSubset NCIT_C63923 @default.
- NCIT_C79833 type Class @default.
- NCIT_C79833 isDefinedBy ncit.owl @default.
- NCIT_C79833 label "Olvimulogene Nanivacirepvec" @default.
- NCIT_C79833 subClassOf NCIT_C129821 @default.
- NCIT_C79833 subClassOf NCIT_C1572 @default.
- NCIT_C79833 subClassOf NCIT_C1908 @default.
- NCIT_C79833 subClassOf NCIT_C1909 @default.
- NCIT_C79833 subClassOf NCIT_C2313 @default.
- NCIT_C79833 subClassOf NCIT_C274 @default.
- NCIT_C79833 subClassOf NCIT_C307 @default.
- NCIT_C79833 subClassOf NCIT_C308 @default.
- NCIT_C79833 subClassOf NCIT_C717 @default.
- NCIT_C79833 subClassOf NCIT_C79833 @default.
- NCIT_C79833 subClassOf NCIT_C923 @default.
- NCIT_C79833 subClassOf NCIT_C96404 @default.