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- NCIT_C79835 IAO_0000115 "An orally bioavailable, ATP-competitive, small-molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor XL888 specifically binds to Hsp90, inhibiting its chaperone function and promoting the proteasomal degradation of oncogenic signaling proteins involved in tumor cell proliferation and survival; inhibition of tumor cell proliferation may result. Hsp90, a chaperone complex protein upregulated in a variety of tumor cell types, regulates the folding and degradation of many oncogenic signaling proteins, including Her-2 and Met." @default.
- NCIT_C79835 NCIT_A32 NCIT_C1909 @default.
- NCIT_C79835 NCIT_A7 NCIT_C17766 @default.
- NCIT_C79835 NCIT_NHC0 "C79835" @default.
- NCIT_C79835 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C79835 NCIT_P107 "Hsp90 Inhibitor XL888" @default.
- NCIT_C79835 NCIT_P108 "Hsp90 Inhibitor XL888" @default.
- NCIT_C79835 NCIT_P208 "CL388445" @default.
- NCIT_C79835 NCIT_P210 "1149705-71-4" @default.
- NCIT_C79835 NCIT_P319 "7M346920EV" @default.
- NCIT_C79835 NCIT_P322 "CTRP" @default.
- NCIT_C79835 NCIT_P322 "FDA" @default.
- NCIT_C79835 NCIT_P322 "GDC" @default.
- NCIT_C79835 NCIT_P329 "629922" @default.
- NCIT_C79835 NCIT_P330 "629922" @default.
- NCIT_C79835 NCIT_P366 "Hsp90_Inhibitor_XL888" @default.
- NCIT_C79835 NCIT_P375 "Hsp90 Inhibitor XL888" @default.
- NCIT_C79835 NCIT_P399 "629922" @default.
- NCIT_C79835 NCIT_R125 NCIT_C17828 @default.
- NCIT_C79835 NCIT_R125 NCIT_C20150 @default.
- NCIT_C79835 NCIT_R125 NCIT_C20480 @default.
- NCIT_C79835 NCIT_R125 NCIT_C40715 @default.
- NCIT_C79835 NCIT_R125 NCIT_C41515 @default.
- NCIT_C79835 NCIT_R125 NCIT_C51037 @default.
- NCIT_C79835 normalizedInformationContent "100" @default.
- NCIT_C79835 referenceCount "1" @default.
- NCIT_C79835 hasExactSynonym "Heat Shock Protein 90 Inhibitor XL888" @default.
- NCIT_C79835 hasExactSynonym "Hsp90 Inhibitor XL888" @default.
- NCIT_C79835 hasExactSynonym "XL-888" @default.
- NCIT_C79835 hasExactSynonym "XL888" @default.
- NCIT_C79835 inSubset NCIT_C116977 @default.
- NCIT_C79835 inSubset NCIT_C116978 @default.
- NCIT_C79835 inSubset NCIT_C128784 @default.
- NCIT_C79835 inSubset NCIT_C157711 @default.
- NCIT_C79835 inSubset NCIT_C157712 @default.
- NCIT_C79835 inSubset NCIT_C176424 @default.
- NCIT_C79835 inSubset NCIT_C177537 @default.
- NCIT_C79835 inSubset NCIT_C63923 @default.
- NCIT_C79835 type Class @default.
- NCIT_C79835 isDefinedBy ncit.owl @default.
- NCIT_C79835 label "Hsp90 Inhibitor XL888" @default.
- NCIT_C79835 subClassOf B0baed43103425da5347059689b4bb577 @default.
- NCIT_C79835 subClassOf B0e4112ecbceeb42daf8c8e3703f35b58 @default.
- NCIT_C79835 subClassOf NCIT_C129824 @default.
- NCIT_C79835 subClassOf NCIT_C156880 @default.
- NCIT_C79835 subClassOf NCIT_C1908 @default.
- NCIT_C79835 subClassOf NCIT_C1909 @default.
- NCIT_C79835 subClassOf NCIT_C2189 @default.
- NCIT_C79835 subClassOf NCIT_C274 @default.
- NCIT_C79835 subClassOf NCIT_C74526 @default.
- NCIT_C79835 subClassOf NCIT_C79835 @default.