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- NCIT_C79841 IAO_0000115 "An orally bioavailable, small-molecule, p38 mitogen-activated protein kinase (MAPK) inhibitor with potential immunomodulating, anti-inflammatory, and antineoplastic activities. Talmapimod specifically binds to and inhibits the phosphorylation of p38 MAPK, which may result in the induction of tumor cell apoptosis, the inhibition of tumor cell proliferation, and the inhibition of tumor angiogenesis. This agent may also enhance proteasome inhibitor-induced apoptosis. p38 MAPK is a serine/threonine protein kinase involved in a MAPK signaling cascade that controls cellular responses to various environmental stresses, cytokines, and endotoxins." @default.
- NCIT_C79841 NCIT_A32 NCIT_C1909 @default.
- NCIT_C79841 NCIT_NHC0 "C79841" @default.
- NCIT_C79841 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C79841 NCIT_P108 "Talmapimod" @default.
- NCIT_C79841 NCIT_P207 "C1541463" @default.
- NCIT_C79841 NCIT_P210 "309913-83-5" @default.
- NCIT_C79841 NCIT_P319 "B1E00KQ6NT" @default.
- NCIT_C79841 NCIT_P322 "FDA" @default.
- NCIT_C79841 NCIT_P322 "GDC" @default.
- NCIT_C79841 NCIT_P329 "387795" @default.
- NCIT_C79841 NCIT_P330 "387795" @default.
- NCIT_C79841 NCIT_P350 "C27H30ClFN4O3" @default.
- NCIT_C79841 NCIT_P366 "Talmapimod" @default.
- NCIT_C79841 NCIT_P375 "Talmapimod" @default.
- NCIT_C79841 NCIT_P399 "387795" @default.
- NCIT_C79841 normalizedInformationContent "100" @default.
- NCIT_C79841 referenceCount "1" @default.
- NCIT_C79841 hasExactSynonym "1H-indole-3-acetamide, 6-Chloro-5-[[(2R,5S)-4-[(4-fluorophenyl)methyl]-2,5-dimethyl-1- piperazinyl]carbonyl]-N,N,1-trimethyl-alpha-oxo-" @default.
- NCIT_C79841 hasExactSynonym "2-[6-Chloro-5-[[(2R,5S)-4-(4-fluorobenzyl)-2,5-dimethylpiperazin-1-yl]carbonyl]-1- methyl-1H-indol-3-yl]-N,N-dimethyl-2-oxoacetamide" @default.
- NCIT_C79841 hasExactSynonym "SCIO 469" @default.
- NCIT_C79841 hasExactSynonym "TALMAPIMOD" @default.
- NCIT_C79841 hasExactSynonym "Talmapimod" @default.
- NCIT_C79841 inSubset NCIT_C128784 @default.
- NCIT_C79841 inSubset NCIT_C157711 @default.
- NCIT_C79841 inSubset NCIT_C157712 @default.
- NCIT_C79841 inSubset NCIT_C176424 @default.
- NCIT_C79841 inSubset NCIT_C177537 @default.
- NCIT_C79841 inSubset NCIT_C63923 @default.
- NCIT_C79841 type Class @default.
- NCIT_C79841 isDefinedBy ncit.owl @default.
- NCIT_C79841 label "Talmapimod" @default.
- NCIT_C79841 subClassOf NCIT_C129824 @default.
- NCIT_C79841 subClassOf NCIT_C129825 @default.
- NCIT_C79841 subClassOf NCIT_C1404 @default.
- NCIT_C79841 subClassOf NCIT_C163758 @default.
- NCIT_C79841 subClassOf NCIT_C1908 @default.
- NCIT_C79841 subClassOf NCIT_C1909 @default.
- NCIT_C79841 subClassOf NCIT_C2149 @default.
- NCIT_C79841 subClassOf NCIT_C2189 @default.
- NCIT_C79841 subClassOf NCIT_C274 @default.
- NCIT_C79841 subClassOf NCIT_C471 @default.
- NCIT_C79841 subClassOf NCIT_C61074 @default.
- NCIT_C79841 subClassOf NCIT_C79841 @default.