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- NCIT_C79842 IAO_0000115 "Autologous human peripheral blood lymphocytes (PBLs), transduced with a retroviral vector encoding both the alpha and beta chains of a T cell receptor (TCR) specific for the carcinoembryonic antigen (CEA), with potential immunostimulating and antineoplastic activities. After transduction, expansion in culture, and reintroduction into the patient, anti-CEA TCR retroviral vector-transduced autologous lymphocytes bind to tumor cells expressing CEA, which may result in cytokine expression, activation and proliferation of T-cells, and a specific cytotoxic T-lymphocyte (CTL) response against CEA-expressing tumor cells. The tumor-associated antigen (TAA) CEA is overexpressed by a variety of cancer cell types, including those of the gastrointestinal tract, lung, and breast." @default.
- NCIT_C79842 NCIT_NHC0 "C79842" @default.
- NCIT_C79842 NCIT_P106 "Cell" @default.
- NCIT_C79842 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C79842 NCIT_P108 "Anti-CEA TCR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes" @default.
- NCIT_C79842 NCIT_P208 "CL388449" @default.
- NCIT_C79842 NCIT_P329 "630382" @default.
- NCIT_C79842 NCIT_P330 "630382" @default.
- NCIT_C79842 NCIT_P366 "Anti-CEA_TCR_Retroviral_Vector-Transduced_Autologous_Peripheral_Blood_Lymphocytes" @default.
- NCIT_C79842 NCIT_P399 "630382" @default.
- NCIT_C79842 normalizedInformationContent "100" @default.
- NCIT_C79842 referenceCount "1" @default.
- NCIT_C79842 hasExactSynonym "Anti-CEA TCR Retroviral Vector-Transduced Autologous PBLs" @default.
- NCIT_C79842 hasExactSynonym "Anti-CEA TCR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes" @default.
- NCIT_C79842 hasExactSynonym "Anti-CEA TCR-Gene Engineered Autologous Lymphocytes" @default.
- NCIT_C79842 inSubset NCIT_C128784 @default.
- NCIT_C79842 inSubset NCIT_C176424 @default.
- NCIT_C79842 type Class @default.
- NCIT_C79842 isDefinedBy ncit.owl @default.
- NCIT_C79842 label "Anti-CEA TCR Retroviral Vector-Transduced Autologous Peripheral Blood Lymphocytes" @default.
- NCIT_C79842 subClassOf NCIT_C129820 @default.
- NCIT_C79842 subClassOf NCIT_C129821 @default.
- NCIT_C79842 subClassOf NCIT_C129826 @default.
- NCIT_C79842 subClassOf NCIT_C138180 @default.
- NCIT_C79842 subClassOf NCIT_C142078 @default.
- NCIT_C79842 subClassOf NCIT_C154231 @default.
- NCIT_C79842 subClassOf NCIT_C1663 @default.
- NCIT_C79842 subClassOf NCIT_C1908 @default.
- NCIT_C79842 subClassOf NCIT_C1909 @default.
- NCIT_C79842 subClassOf NCIT_C1962 @default.
- NCIT_C79842 subClassOf NCIT_C274 @default.
- NCIT_C79842 subClassOf NCIT_C2841 @default.
- NCIT_C79842 subClassOf NCIT_C307 @default.
- NCIT_C79842 subClassOf NCIT_C308 @default.
- NCIT_C79842 subClassOf NCIT_C79842 @default.
- NCIT_C79842 subClassOf NCIT_C923 @default.