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- NCIT_C79845 IAO_0000115 "A replication-defective (ICP4-deleted) herpes simplex virus type 1 (HSV-1) viral vector expressing the human preproenkephalin A (PPE) gene with potential antinociceptive activity. Upon intradermal administration, PPE-expressing replication-defective HSV-1 vector NP2 is transported by retrograde axonal transport to the dorsal root ganglion (DRG) and becomes dormant. In the DRG, the vector transduces sensory neurons with high efficiency, delivering the engineered PPE gene; transduced neurons then express the protein proenkephalin A, the precursor for Met- and Leu-enkephalin. After proteolytic cleavage from proenkephalin A in the DRG neuronal cytosol, transgene-mediated Met- and Leu-enkephalin bind to mu and gamma- opioid receptors, which may result in the inhibition of nociceptive neurotransmission." @default.
- NCIT_C79845 NCIT_NHC0 "C79845" @default.
- NCIT_C79845 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C79845 NCIT_P107 "PPE-Expressing Replication-Defective HSV-1 Vector NP2" @default.
- NCIT_C79845 NCIT_P108 "PPE-Expressing Replication-Defective HSV-1 Vector NP2" @default.
- NCIT_C79845 NCIT_P208 "CL388508" @default.
- NCIT_C79845 NCIT_P322 "CTRP" @default.
- NCIT_C79845 NCIT_P329 "630943" @default.
- NCIT_C79845 NCIT_P330 "630943" @default.
- NCIT_C79845 NCIT_P366 "PPE-Expressing_Nonreplicating_HSV-1-Based_Vector_NP2" @default.
- NCIT_C79845 NCIT_P399 "630943" @default.
- NCIT_C79845 normalizedInformationContent "100" @default.
- NCIT_C79845 referenceCount "1" @default.
- NCIT_C79845 hasExactSynonym "NP2" @default.
- NCIT_C79845 hasExactSynonym "PPE-Expressing Replication-Defective HSV-1 Vector NP2" @default.
- NCIT_C79845 hasExactSynonym "Preproenkephalin-Expressing Replication-Defective Herpes Simplex Virus-1 Vector NP2" @default.
- NCIT_C79845 inSubset NCIT_C116977 @default.
- NCIT_C79845 inSubset NCIT_C116978 @default.
- NCIT_C79845 inSubset NCIT_C176424 @default.
- NCIT_C79845 type Class @default.
- NCIT_C79845 isDefinedBy ncit.owl @default.
- NCIT_C79845 label "PPE-Expressing Replication-Defective HSV-1 Vector NP2" @default.
- NCIT_C79845 subClassOf NCIT_C1908 @default.
- NCIT_C79845 subClassOf NCIT_C1909 @default.
- NCIT_C79845 subClassOf NCIT_C1962 @default.
- NCIT_C79845 subClassOf NCIT_C307 @default.
- NCIT_C79845 subClassOf NCIT_C61199 @default.
- NCIT_C79845 subClassOf NCIT_C79845 @default.