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- NCIT_C80046 IAO_0000115 "A whole cell melanoma cancer vaccine with potential immunostimulating and antineoplastic activities. B16alphaGal melanoma vaccine contains three types of human melanoma cell lines that are genetically engineered to express the alpha(1,3)-galactosyl (alphaGal) epitope on cell surfaces. The agent stimulates a hyperacute rejection of whole melanoma cancer cells expressing alphaGal epitopes, initiated by opsonization by anti-alphaGal antibodies and followed by antibody-dependent cell-mediated cytotoxicity (ADCC) and cell lysis. This results in the stimulation of a broader cytotoxic T-lymphocyte response (CTL) directed against tumor antigens on melanoma cells that do not express alphaGal. AlphaGal is not normally expressed in humans because alpha(1,3)-galactosyltransferase (Alpha-GT), the enzyme that catalyzes the synthesis of alphaGal epitopes on glycoproteins and glycolipids, is not naturally present in humans and other primates." @default.
- NCIT_C80046 NCIT_NHC0 "C80046" @default.
- NCIT_C80046 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C80046 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C80046 NCIT_P107 "B16alphaGal Melanoma Vaccine" @default.
- NCIT_C80046 NCIT_P108 "B16alphaGal Melanoma Vaccine" @default.
- NCIT_C80046 NCIT_P208 "CL388386" @default.
- NCIT_C80046 NCIT_P322 "CTRP" @default.
- NCIT_C80046 NCIT_P329 "615145" @default.
- NCIT_C80046 NCIT_P330 "615145" @default.
- NCIT_C80046 NCIT_P366 "B16alphaGal_Melanoma_Vaccine" @default.
- NCIT_C80046 NCIT_P399 "615145" @default.
- NCIT_C80046 normalizedInformationContent "100" @default.
- NCIT_C80046 referenceCount "1" @default.
- NCIT_C80046 hasExactSynonym "B16alphaGal Melanoma Vaccine" @default.
- NCIT_C80046 hasExactSynonym "Hyperacute Melanoma" @default.
- NCIT_C80046 inSubset NCIT_C116977 @default.
- NCIT_C80046 inSubset NCIT_C116978 @default.
- NCIT_C80046 inSubset NCIT_C128784 @default.
- NCIT_C80046 inSubset NCIT_C176424 @default.
- NCIT_C80046 type Class @default.
- NCIT_C80046 isDefinedBy ncit.owl @default.
- NCIT_C80046 label "B16alphaGal Melanoma Vaccine" @default.
- NCIT_C80046 subClassOf NCIT_C129820 @default.
- NCIT_C80046 subClassOf NCIT_C1663 @default.
- NCIT_C80046 subClassOf NCIT_C1908 @default.
- NCIT_C80046 subClassOf NCIT_C1909 @default.
- NCIT_C80046 subClassOf NCIT_C2517 @default.
- NCIT_C80046 subClassOf NCIT_C274 @default.
- NCIT_C80046 subClassOf NCIT_C307 @default.
- NCIT_C80046 subClassOf NCIT_C308 @default.
- NCIT_C80046 subClassOf NCIT_C80046 @default.
- NCIT_C80046 subClassOf NCIT_C923 @default.