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- NCIT_C80048 IAO_0000115 "A combination therapy consisting of the prodrug tretazicar and the enzyme co-substrate caricotamide with potential antineoplastic activity. In the presence of separately and simultaneously administered caricotamide, tretazicar is converted to the short-lived cytotoxic DNA cross-linking agent dinitrobenzamide by NAD(P)H quinine oxidoreductase 2 (NQO2), resulting in the inhibition of DNA replication and the induction of apoptosis. NQO2 has been found to be elevated in certain cancers such as hepatocellular carcinoma (HCC)." @default.
- NCIT_C80048 NCIT_A32 NCIT_C1909 @default.
- NCIT_C80048 NCIT_NHC0 "C80048" @default.
- NCIT_C80048 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C80048 NCIT_P108 "Caricotamide/Tretazicar" @default.
- NCIT_C80048 NCIT_P208 "CL388385" @default.
- NCIT_C80048 NCIT_P322 "GDC" @default.
- NCIT_C80048 NCIT_P329 "615142" @default.
- NCIT_C80048 NCIT_P330 "615142" @default.
- NCIT_C80048 NCIT_P366 "Caricotamide_Tretazicar" @default.
- NCIT_C80048 NCIT_P375 "Caricotamide/Tretazicar" @default.
- NCIT_C80048 NCIT_P399 "615142" @default.
- NCIT_C80048 normalizedInformationContent "100" @default.
- NCIT_C80048 referenceCount "1" @default.
- NCIT_C80048 hasExactSynonym "Caricotamide/Tretazicar" @default.
- NCIT_C80048 hasExactSynonym "EP-0152R/CB1954" @default.
- NCIT_C80048 hasExactSynonym "Prolarix" @default.
- NCIT_C80048 inSubset NCIT_C128784 @default.
- NCIT_C80048 inSubset NCIT_C157711 @default.
- NCIT_C80048 inSubset NCIT_C157712 @default.
- NCIT_C80048 inSubset NCIT_C176424 @default.
- NCIT_C80048 inSubset NCIT_C177537 @default.
- NCIT_C80048 type Class @default.
- NCIT_C80048 isDefinedBy ncit.owl @default.
- NCIT_C80048 label "Caricotamide/Tretazicar" @default.
- NCIT_C80048 subClassOf NCIT_C186664 @default.
- NCIT_C80048 subClassOf NCIT_C1908 @default.
- NCIT_C80048 subClassOf NCIT_C1909 @default.
- NCIT_C80048 subClassOf NCIT_C25760 @default.
- NCIT_C80048 subClassOf NCIT_C274 @default.
- NCIT_C80048 subClassOf NCIT_C2842 @default.
- NCIT_C80048 subClassOf NCIT_C80048 @default.