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- NCIT_C80059 IAO_0000115 "An orally bioavailable inhibitor of poly (ADP-ribose) polymerase (PARP) types 1 and 2 (PARP-1 and -2), with antineoplastic activity. Upon administration, niraparib binds to and inhibits the activity of PARP-1 and -2, thereby inhibiting PARP-1 and -2-mediated DNA repair, enhancing the accumulation of DNA strand breaks, promoting genomic instability and resulting in apoptosis. The PARP family of proteins catalyzes post-translational ADP-ribosylation of nuclear proteins and is activated by single-strand DNA (ssDNA) breaks." @default.
- NCIT_C80059 NCIT_A32 NCIT_C1909 @default.
- NCIT_C80059 NCIT_A5 NCIT_C133238 @default.
- NCIT_C80059 NCIT_A7 NCIT_C104720 @default.
- NCIT_C80059 NCIT_A7 NCIT_C48215 @default.
- NCIT_C80059 NCIT_NHC0 "C80059" @default.
- NCIT_C80059 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C80059 NCIT_P107 "Niraparib" @default.
- NCIT_C80059 NCIT_P108 "Niraparib" @default.
- NCIT_C80059 NCIT_P207 "C2744440" @default.
- NCIT_C80059 NCIT_P210 "1038915-60-4" @default.
- NCIT_C80059 NCIT_P319 "HMC2H89N35" @default.
- NCIT_C80059 NCIT_P322 "CTRP" @default.
- NCIT_C80059 NCIT_P322 "FDA" @default.
- NCIT_C80059 NCIT_P322 "GDC" @default.
- NCIT_C80059 NCIT_P329 "615263" @default.
- NCIT_C80059 NCIT_P330 "615263" @default.
- NCIT_C80059 NCIT_P366 "PARP_Inhibitor_MK4827" @default.
- NCIT_C80059 NCIT_P375 "Niraparib" @default.
- NCIT_C80059 NCIT_P399 "615263" @default.
- NCIT_C80059 NCIT_R146 NCIT_C104101 @default.
- NCIT_C80059 NCIT_R146 NCIT_C16554 @default.
- NCIT_C80059 NCIT_R146 NCIT_C17021 @default.
- NCIT_C80059 NCIT_R146 NCIT_C17210 @default.
- NCIT_C80059 NCIT_R146 NCIT_C17434 @default.
- NCIT_C80059 NCIT_R146 NCIT_C20027 @default.
- NCIT_C80059 NCIT_R146 NCIT_C21170 @default.
- NCIT_C80059 NCIT_R146 NCIT_C26548 @default.
- NCIT_C80059 NCIT_R146 NCIT_C48215 @default.
- NCIT_C80059 normalizedInformationContent "100" @default.
- NCIT_C80059 referenceCount "1" @default.
- NCIT_C80059 hasExactSynonym "MK-4827" @default.
- NCIT_C80059 hasExactSynonym "MK4827" @default.
- NCIT_C80059 hasExactSynonym "NIRAPARIB" @default.
- NCIT_C80059 hasExactSynonym "Niraparib" @default.
- NCIT_C80059 inSubset NCIT_C116977 @default.
- NCIT_C80059 inSubset NCIT_C116978 @default.
- NCIT_C80059 inSubset NCIT_C128784 @default.
- NCIT_C80059 inSubset NCIT_C157711 @default.
- NCIT_C80059 inSubset NCIT_C157712 @default.
- NCIT_C80059 inSubset NCIT_C176424 @default.
- NCIT_C80059 inSubset NCIT_C177537 @default.
- NCIT_C80059 inSubset NCIT_C63923 @default.
- NCIT_C80059 type Class @default.
- NCIT_C80059 isDefinedBy ncit.owl @default.
- NCIT_C80059 label "Niraparib" @default.
- NCIT_C80059 subClassOf NCIT_C163758 @default.
- NCIT_C80059 subClassOf NCIT_C1908 @default.
- NCIT_C80059 subClassOf NCIT_C1909 @default.
- NCIT_C80059 subClassOf NCIT_C274 @default.
- NCIT_C80059 subClassOf NCIT_C471 @default.
- NCIT_C80059 subClassOf NCIT_C62554 @default.
- NCIT_C80059 subClassOf NCIT_C80059 @default.