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- NCIT_C80063 IAO_0000115 "An orally bioavailable, cyclopamine-derived inhibitor of the Hedgehog (Hh) pathway with potential antineoplastic activity. Specifically, patidegib binds to and inhibits the cell membrane-spanning G-protein coupled receptor SMO, which may result in the suppression of Hh pathway signaling and a decrease in tumor cell proliferation and survival. SMO is activated upon binding of Hh ligand to the cell surface receptor Patched (PTCH); inappropriate activation of Hh signaling and uncontrolled cellular proliferation may be associated with SMO mutations. The Hh signaling pathway plays an important role in proliferation of neuronal precursor cells in the developing cerebellum and other tissues." @default.
- NCIT_C80063 NCIT_A32 NCIT_C1909 @default.
- NCIT_C80063 NCIT_A7 NCIT_C29980 @default.
- NCIT_C80063 NCIT_NHC0 "C80063" @default.
- NCIT_C80063 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C80063 NCIT_P107 "Patidegib" @default.
- NCIT_C80063 NCIT_P108 "Patidegib" @default.
- NCIT_C80063 NCIT_P207 "C2703211" @default.
- NCIT_C80063 NCIT_P210 "1037210-93-7" @default.
- NCIT_C80063 NCIT_P319 "JT96FPU35X" @default.
- NCIT_C80063 NCIT_P322 "CTRP" @default.
- NCIT_C80063 NCIT_P322 "FDA" @default.
- NCIT_C80063 NCIT_P322 "GDC" @default.
- NCIT_C80063 NCIT_P329 "616875" @default.
- NCIT_C80063 NCIT_P330 "616875" @default.
- NCIT_C80063 NCIT_P350 "C29H48N2O3S" @default.
- NCIT_C80063 NCIT_P366 "Smoothened_Antagonist_IPI-926" @default.
- NCIT_C80063 NCIT_P375 "Patidegib" @default.
- NCIT_C80063 NCIT_P399 "616875" @default.
- NCIT_C80063 normalizedInformationContent "100" @default.
- NCIT_C80063 referenceCount "1" @default.
- NCIT_C80063 hasExactSynonym "FIN-5" @default.
- NCIT_C80063 hasExactSynonym "IP9 Free Base" @default.
- NCIT_C80063 hasExactSynonym "IPI-926 Free Base" @default.
- NCIT_C80063 hasExactSynonym "IPI-926" @default.
- NCIT_C80063 hasExactSynonym "PATIDEGIB" @default.
- NCIT_C80063 hasExactSynonym "Patidegib" @default.
- NCIT_C80063 hasExactSynonym "Saridegib" @default.
- NCIT_C80063 hasExactSynonym "Smoothened Antagonist IPI-926" @default.
- NCIT_C80063 inSubset NCIT_C116977 @default.
- NCIT_C80063 inSubset NCIT_C116978 @default.
- NCIT_C80063 inSubset NCIT_C128784 @default.
- NCIT_C80063 inSubset NCIT_C157711 @default.
- NCIT_C80063 inSubset NCIT_C157712 @default.
- NCIT_C80063 inSubset NCIT_C176424 @default.
- NCIT_C80063 inSubset NCIT_C177537 @default.
- NCIT_C80063 inSubset NCIT_C63923 @default.
- NCIT_C80063 type Class @default.
- NCIT_C80063 isDefinedBy ncit.owl @default.
- NCIT_C80063 label "Patidegib" @default.
- NCIT_C80063 subClassOf NCIT_C155725 @default.
- NCIT_C80063 subClassOf NCIT_C163758 @default.
- NCIT_C80063 subClassOf NCIT_C188731 @default.
- NCIT_C80063 subClassOf NCIT_C1908 @default.
- NCIT_C80063 subClassOf NCIT_C1909 @default.
- NCIT_C80063 subClassOf NCIT_C2189 @default.
- NCIT_C80063 subClassOf NCIT_C274 @default.
- NCIT_C80063 subClassOf NCIT_C80063 @default.