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- NCIT_C80120 IAO_0000115 "Anhydrous form of a synthetic imidazole third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix." @default.
- NCIT_C80120 NCIT_NHC0 "C80120" @default.
- NCIT_C80120 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C80120 NCIT_P108 "Zoledronic Acid Anhydrous" @default.
- NCIT_C80120 NCIT_P207 "C2700334" @default.
- NCIT_C80120 NCIT_P210 "118072-93-8" @default.
- NCIT_C80120 NCIT_P319 "70HZ18PH24" @default.
- NCIT_C80120 NCIT_P322 "FDA" @default.
- NCIT_C80120 NCIT_P350 "C5H10N2O7P2" @default.
- NCIT_C80120 NCIT_P366 "Zolendronic_Acid_Anhydrous" @default.
- NCIT_C80120 NCIT_P368 "CHEBI:46557" @default.
- NCIT_C80120 normalizedInformationContent "100" @default.
- NCIT_C80120 referenceCount "1" @default.
- NCIT_C80120 hasExactSynonym "ZOLEDRONIC ACID ANHYDROUS" @default.
- NCIT_C80120 hasExactSynonym "Zoledronic Acid Anhydrous" @default.
- NCIT_C80120 inSubset NCIT_C63923 @default.
- NCIT_C80120 type Class @default.
- NCIT_C80120 isDefinedBy ncit.owl @default.
- NCIT_C80120 label "Zoledronic Acid Anhydrous" @default.
- NCIT_C80120 subClassOf NCIT_C1908 @default.
- NCIT_C80120 subClassOf NCIT_C1913 @default.
- NCIT_C80120 subClassOf NCIT_C443 @default.
- NCIT_C80120 subClassOf NCIT_C718 @default.
- NCIT_C80120 subClassOf NCIT_C80120 @default.