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- NCIT_C80325 IAO_0000115 "The trisodium salt form of zoledronate, a synthetic imidazole, third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix." @default.
- NCIT_C80325 NCIT_A6 NCIT_C1699 @default.
- NCIT_C80325 NCIT_NHC0 "C80325" @default.
- NCIT_C80325 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C80325 NCIT_P108 "Zoledronate Trisodium" @default.
- NCIT_C80325 NCIT_P207 "C2700333" @default.
- NCIT_C80325 NCIT_P210 "165800-08-8" @default.
- NCIT_C80325 NCIT_P319 "ARL915IH66" @default.
- NCIT_C80325 NCIT_P322 "FDA" @default.
- NCIT_C80325 NCIT_P366 "Zoledronate_Trisodium" @default.
- NCIT_C80325 normalizedInformationContent "100" @default.
- NCIT_C80325 referenceCount "1" @default.
- NCIT_C80325 hasExactSynonym "CGP 42446B" @default.
- NCIT_C80325 hasExactSynonym "Phosphonic Acid, (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bis-, Trisodium Salt Tetrahydrate (5:2)" @default.
- NCIT_C80325 hasExactSynonym "Trisodium Hydrogen (1-hydroxy-2-imidazol-1-ylethylidene)diphosphonate, Hydrate (5:2)" @default.
- NCIT_C80325 hasExactSynonym "ZOLEDRONATE TRISODIUM" @default.
- NCIT_C80325 hasExactSynonym "Zoledronate Trisodium" @default.
- NCIT_C80325 inSubset NCIT_C63923 @default.
- NCIT_C80325 type Class @default.
- NCIT_C80325 isDefinedBy ncit.owl @default.
- NCIT_C80325 label "Zoledronate Trisodium" @default.
- NCIT_C80325 subClassOf NCIT_C1908 @default.
- NCIT_C80325 subClassOf NCIT_C1909 @default.
- NCIT_C80325 subClassOf NCIT_C1913 @default.
- NCIT_C80325 subClassOf NCIT_C443 @default.
- NCIT_C80325 subClassOf NCIT_C67439 @default.
- NCIT_C80325 subClassOf NCIT_C718 @default.
- NCIT_C80325 subClassOf NCIT_C78281 @default.
- NCIT_C80325 subClassOf NCIT_C80325 @default.