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- NCIT_C80339 IAO_0000115 "A methylxanthine and derivative of theophylline. Proxyphylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Proxyphylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart." @default.
- NCIT_C80339 NCIT_NHC0 "C80339" @default.
- NCIT_C80339 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C80339 NCIT_P108 "Proxyphylline" @default.
- NCIT_C80339 NCIT_P175 "163343" @default.
- NCIT_C80339 NCIT_P207 "C0072511" @default.
- NCIT_C80339 NCIT_P210 "603-00-9" @default.
- NCIT_C80339 NCIT_P319 "13G1DMN4P0" @default.
- NCIT_C80339 NCIT_P322 "FDA" @default.
- NCIT_C80339 NCIT_P350 "C10H14N4O3" @default.
- NCIT_C80339 NCIT_P366 "Proxyphylline" @default.
- NCIT_C80339 normalizedInformationContent "100" @default.
- NCIT_C80339 referenceCount "1" @default.
- NCIT_C80339 hasExactSynonym "1,3-Dimethyl-7-(2-hydroxypropyl)xanthine" @default.
- NCIT_C80339 hasExactSynonym "1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-7-(2-hydroxypropyl)-" @default.
- NCIT_C80339 hasExactSynonym "2-Hydroxypropyl-7-theophylline" @default.
- NCIT_C80339 hasExactSynonym "Beta-Oxypropyltheophyllin" @default.
- NCIT_C80339 hasExactSynonym "Brontyl" @default.
- NCIT_C80339 hasExactSynonym "PROXYPHYLLINE" @default.
- NCIT_C80339 hasExactSynonym "Proxyphylline" @default.
- NCIT_C80339 hasExactSynonym "Theon" @default.
- NCIT_C80339 inSubset NCIT_C63923 @default.
- NCIT_C80339 type Class @default.
- NCIT_C80339 isDefinedBy ncit.owl @default.
- NCIT_C80339 label "Proxyphylline" @default.
- NCIT_C80339 subClassOf NCIT_C1908 @default.
- NCIT_C80339 subClassOf NCIT_C1909 @default.
- NCIT_C80339 subClassOf NCIT_C29712 @default.
- NCIT_C80339 subClassOf NCIT_C319 @default.
- NCIT_C80339 subClassOf NCIT_C471 @default.
- NCIT_C80339 subClassOf NCIT_C744 @default.
- NCIT_C80339 subClassOf NCIT_C78273 @default.
- NCIT_C80339 subClassOf NCIT_C80339 @default.