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- NCIT_C809 IAO_0000115 "A phytotoxin and lectin comprised of a homodimer of ricin toxin A and B chains derived from the seeds of Ricinus communis, the castor oil plant, with protein synthesis inhibitory activity and extremely high cytotoxicity. Following ingestion, inhalation or injection of ricin, the B chain binds to complex carbohydrates containing either terminal N-acetylgalactosamine or beta-1,4-linked galactose residues on the surface of cells. Subsequently, the ricin A/B heterodimer is internalized and undergoes retrograde transport to the endoplasmic reticulum (ER). In the ER, the A chain, which has enzymatic activity that is sterically hindered by the B chain, is proteolytically released from the heterodimer by protein disulfide isomerase. In the ER, the free A chain has N-glycosidase activity that cleaves 28S rRNA. This enzymatic cleavage disrupts the ribosome, halts protein synthesis, and can lead to cell death. The extreme cytotoxicity of ricin makes it an attractive candidate for artificial fusion with binding proteins to create cell-type-specific toxins." @default.
- NCIT_C809 NCIT_NHC0 "C809" @default.
- NCIT_C809 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C809 NCIT_P106 "Hazardous or Poisonous Substance" @default.
- NCIT_C809 NCIT_P108 "Ricin" @default.
- NCIT_C809 NCIT_P175 "9902" @default.
- NCIT_C809 NCIT_P207 "C0035569" @default.
- NCIT_C809 NCIT_P210 "9009-86-3" @default.
- NCIT_C809 NCIT_P319 "U6E7R9OE4R" @default.
- NCIT_C809 NCIT_P322 "CDISC" @default.
- NCIT_C809 NCIT_P322 "FDA" @default.
- NCIT_C809 NCIT_P325 "The biotoxin ricin." @default.
- NCIT_C809 NCIT_P366 "Ricin" @default.
- NCIT_C809 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C809 referenceCount "2" @default.
- NCIT_C809 hasExactSynonym "RICIN" @default.
- NCIT_C809 hasExactSynonym "Ricin" @default.
- NCIT_C809 hasExactSynonym "Ricinus Communis Agglutinin II" @default.
- NCIT_C809 inSubset NCIT_C160930 @default.
- NCIT_C809 inSubset NCIT_C61410 @default.
- NCIT_C809 inSubset NCIT_C63923 @default.
- NCIT_C809 inSubset NCIT_C77526 @default.
- NCIT_C809 type Class @default.
- NCIT_C809 isDefinedBy ncit.owl @default.
- NCIT_C809 label "Ricin" @default.
- NCIT_C809 subClassOf NCIT_C1908 @default.
- NCIT_C809 subClassOf NCIT_C1909 @default.
- NCIT_C809 subClassOf NCIT_C1923 @default.
- NCIT_C809 subClassOf NCIT_C1932 @default.
- NCIT_C809 subClassOf NCIT_C784 @default.
- NCIT_C809 subClassOf NCIT_C809 @default.
- NCIT_C809 subClassOf NCIT_C894 @default.