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- NCIT_C80972 IAO_0000115 "A Fab fragment of a recombinant, humanized monoclonal antibody directed against the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) and conjugated to polyethylene glycol (PEG), with anti-inflammatory activity. Upon administration, certolizumab binds to TNF-alpha and prevents the interaction of this cytokine with endogenous cell surface receptors, thereby rendering TNF-alpha inactive and inhibiting TNF-mediated inflammatory responses. TNF-alpha is a protein involved in inflammation, cell survival, and apoptosis. Pegylation of certolizumab allows for an improved pharmacokinetic profile." @default.
- NCIT_C80972 NCIT_NHC0 "C80972" @default.
- NCIT_C80972 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C80972 NCIT_P108 "Certolizumab Pegol" @default.
- NCIT_C80972 NCIT_P207 "C1872109" @default.
- NCIT_C80972 NCIT_P210 "428863-50-7" @default.
- NCIT_C80972 NCIT_P319 "UMD07X179E" @default.
- NCIT_C80972 NCIT_P322 "FDA" @default.
- NCIT_C80972 NCIT_P329 "791843" @default.
- NCIT_C80972 NCIT_P330 "791843" @default.
- NCIT_C80972 NCIT_P350 "C19H30N5O8S(C2H4O)n(C2H4O)n" @default.
- NCIT_C80972 NCIT_P366 "Certolizumab_Pegol" @default.
- NCIT_C80972 NCIT_P368 "CHEBI:63585" @default.
- NCIT_C80972 NCIT_P399 "791843" @default.
- NCIT_C80972 NCIT_R124 NCIT_C17710 @default.
- NCIT_C80972 NCIT_R124 NCIT_C17828 @default.
- NCIT_C80972 NCIT_R124 NCIT_C18219 @default.
- NCIT_C80972 NCIT_R124 NCIT_C19986 @default.
- NCIT_C80972 NCIT_R124 NCIT_C40474 @default.
- NCIT_C80972 normalizedInformationContent "100" @default.
- NCIT_C80972 referenceCount "1" @default.
- NCIT_C80972 hasExactSynonym "CDP 870" @default.
- NCIT_C80972 hasExactSynonym "CDP870" @default.
- NCIT_C80972 hasExactSynonym "CERTOLIZUMAB PEGOL" @default.
- NCIT_C80972 hasExactSynonym "CZP" @default.
- NCIT_C80972 hasExactSynonym "Certolizumab Pegol" @default.
- NCIT_C80972 hasExactSynonym "Cimzia" @default.
- NCIT_C80972 hasExactSynonym "PHA-738144" @default.
- NCIT_C80972 inSubset NCIT_C176424 @default.
- NCIT_C80972 inSubset NCIT_C63923 @default.
- NCIT_C80972 type Class @default.
- NCIT_C80972 isDefinedBy ncit.owl @default.
- NCIT_C80972 label "Certolizumab Pegol" @default.
- NCIT_C80972 subClassOf NCIT_C1908 @default.
- NCIT_C80972 subClassOf NCIT_C1909 @default.
- NCIT_C80972 subClassOf NCIT_C20401 @default.
- NCIT_C80972 subClassOf NCIT_C307 @default.
- NCIT_C80972 subClassOf NCIT_C308 @default.
- NCIT_C80972 subClassOf NCIT_C80972 @default.