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- NCIT_C81114 IAO_0000115 "The tartrate salt form of metyrapone, a pyridine derivative and an inhibitor of steroid 11-beta-hydroxylase with anti-adrenal activity. Metyrapone inhibits steroid 11-beta-hydroxylase, thereby inhibiting the synthesis of cortisol from 11-deoxycortisol, and corticosterone, the precursor of aldosterone, from deoxycorticosterone in the adrenal gland. Removal of the negative feedback mechanism exerted by cortisol results in increased adrenocorticotropic hormone (ACTH) secretion by the pituitary gland. In turn, continued stimulation of the adrenal gland by ACTH results in the accumulation of corticoid precursors, 11-deoxycortisol and deoxycorticosterone. These corticoid precursors are excreted in urine and may be used as indicators for hypothalamic-pituitary ACTH function." @default.
- NCIT_C81114 NCIT_A6 NCIT_C47619 @default.
- NCIT_C81114 NCIT_NHC0 "C81114" @default.
- NCIT_C81114 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C81114 NCIT_P108 "Metyrapone Tartrate" @default.
- NCIT_C81114 NCIT_P207 "C2825460" @default.
- NCIT_C81114 NCIT_P210 "908-35-0" @default.
- NCIT_C81114 NCIT_P319 "B6DRB5ZI7P" @default.
- NCIT_C81114 NCIT_P322 "FDA" @default.
- NCIT_C81114 NCIT_P350 "C14H14N2O.2C4H6O6" @default.
- NCIT_C81114 NCIT_P366 "Metyrapone_Tartrate" @default.
- NCIT_C81114 normalizedInformationContent "100" @default.
- NCIT_C81114 referenceCount "1" @default.
- NCIT_C81114 hasExactSynonym "METYRAPONE TARTRATE" @default.
- NCIT_C81114 hasExactSynonym "Metyrapone Tartrate" @default.
- NCIT_C81114 inSubset NCIT_C63923 @default.
- NCIT_C81114 type Class @default.
- NCIT_C81114 isDefinedBy ncit.owl @default.
- NCIT_C81114 label "Metyrapone Tartrate" @default.
- NCIT_C81114 subClassOf NCIT_C1908 @default.
- NCIT_C81114 subClassOf NCIT_C1909 @default.
- NCIT_C81114 subClassOf NCIT_C471 @default.
- NCIT_C81114 subClassOf NCIT_C81114 @default.