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- NCIT_C81372 IAO_0000115 "An orally available, alpha-1 adrenoreceptor (alpha-1a) selective antagonist that can be used to relieve symptoms of benign prostate hyperplasia (BPH). Upon administration, silodosin selectively binds alpha-1a receptors located in the human prostate and bladder with high affinity and blocks signaling pathways mediated by alpha-1a. Blockade of these receptors causes smooth muscle relaxation, lowers intraurethral pressure, and results in improved urine flow and a reduction in the symptoms of BPH, such as difficulty with urinating, painful urination, urinary frequency and incomplete bladder emptying. In addition, silodosin may be used to improve lower urinary tract symptoms, which can occur after receiving radiation therapy for prostate cancer." @default.
- NCIT_C81372 NCIT_NHC0 "C81372" @default.
- NCIT_C81372 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C81372 NCIT_P108 "Silodosin" @default.
- NCIT_C81372 NCIT_P207 "C1870115" @default.
- NCIT_C81372 NCIT_P210 "160970-54-7" @default.
- NCIT_C81372 NCIT_P319 "CUZ39LUY82" @default.
- NCIT_C81372 NCIT_P322 "FDA" @default.
- NCIT_C81372 NCIT_P329 "764149" @default.
- NCIT_C81372 NCIT_P330 "764149" @default.
- NCIT_C81372 NCIT_P350 "C25H32F3N3O4" @default.
- NCIT_C81372 NCIT_P366 "Silodosin" @default.
- NCIT_C81372 NCIT_P399 "764149" @default.
- NCIT_C81372 normalizedInformationContent "100" @default.
- NCIT_C81372 referenceCount "1" @default.
- NCIT_C81372 hasExactSynonym "Rapaflo" @default.
- NCIT_C81372 hasExactSynonym "Rapilif" @default.
- NCIT_C81372 hasExactSynonym "SILODOSIN" @default.
- NCIT_C81372 hasExactSynonym "Silodosin" @default.
- NCIT_C81372 hasExactSynonym "Silodyx" @default.
- NCIT_C81372 hasExactSynonym "Urief" @default.
- NCIT_C81372 hasExactSynonym "Urorec" @default.
- NCIT_C81372 inSubset NCIT_C176424 @default.
- NCIT_C81372 inSubset NCIT_C63923 @default.
- NCIT_C81372 type Class @default.
- NCIT_C81372 isDefinedBy ncit.owl @default.
- NCIT_C81372 label "Silodosin" @default.
- NCIT_C81372 subClassOf NCIT_C1908 @default.
- NCIT_C81372 subClassOf NCIT_C1909 @default.
- NCIT_C81372 subClassOf NCIT_C29713 @default.
- NCIT_C81372 subClassOf NCIT_C29747 @default.
- NCIT_C81372 subClassOf NCIT_C72900 @default.
- NCIT_C81372 subClassOf NCIT_C78272 @default.
- NCIT_C81372 subClassOf NCIT_C81372 @default.