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- NCIT_C81532 IAO_0000115 "An antilipidemic agent based on the carbon skeleton of cholesterol. Colestolone targets sterol regulatory element binding protein (SREBP) which reduces the transcription of the 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) gene, the rate-limiting enzyme in the sterol pathway. Colestolone is also metabolized by cells into polar sterols, which are known to inhibit HMGCR enzymatic activity." @default.
- NCIT_C81532 NCIT_NHC0 "C81532" @default.
- NCIT_C81532 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C81532 NCIT_P108 "Colestolone" @default.
- NCIT_C81532 NCIT_P207 "C2825672" @default.
- NCIT_C81532 NCIT_P210 "50673-97-7" @default.
- NCIT_C81532 NCIT_P319 "5P8396T5XF" @default.
- NCIT_C81532 NCIT_P322 "FDA" @default.
- NCIT_C81532 NCIT_P350 "C27H44O2" @default.
- NCIT_C81532 NCIT_P366 "Colestolone" @default.
- NCIT_C81532 NCIT_P368 "CHEBI:61829" @default.
- NCIT_C81532 normalizedInformationContent "100" @default.
- NCIT_C81532 referenceCount "1" @default.
- NCIT_C81532 hasExactSynonym "COLESTOLONE" @default.
- NCIT_C81532 hasExactSynonym "Colestolone" @default.
- NCIT_C81532 inSubset NCIT_C63923 @default.
- NCIT_C81532 type Class @default.
- NCIT_C81532 isDefinedBy ncit.owl @default.
- NCIT_C81532 label "Colestolone" @default.
- NCIT_C81532 subClassOf NCIT_C1908 @default.
- NCIT_C81532 subClassOf NCIT_C1909 @default.
- NCIT_C81532 subClassOf NCIT_C29703 @default.
- NCIT_C81532 subClassOf NCIT_C78276 @default.
- NCIT_C81532 subClassOf NCIT_C81532 @default.