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- NCIT_C81569 IAO_0000115 "The sodium salt form of ifetroban, an orally bioavailable thromboxane (TxA2) and prostaglandin H2 (PGH2) (TP) receptor antagonist, with anti-thrombotic, anti-hypertensive, anti-asthmatic and potential anti-metastatic activities. Upon administration, ifetroban targets and binds to TxA2 and PGH2 receptors, thereby preventing the activity of both TxA2 and PGH2 and disrupting their downstream signaling pathways. This prevents platelet activation, aggregation and thrombosis. It also prevents vascular constriction and causes vasodilation. In addition, as cancer cells use platelets to metastasize to different parts of the body, ifetroban can reduce the stickiness of the platelets and prevent metastasis. TxA2 causes vascular contraction and platelet activation." @default.
- NCIT_C81569 NCIT_A6 NCIT_C81570 @default.
- NCIT_C81569 NCIT_NHC0 "C81569" @default.
- NCIT_C81569 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C81569 NCIT_P108 "Ifetroban Sodium" @default.
- NCIT_C81569 NCIT_P207 "C2825686" @default.
- NCIT_C81569 NCIT_P210 "156715-37-6" @default.
- NCIT_C81569 NCIT_P319 "48IJA0E92C" @default.
- NCIT_C81569 NCIT_P322 "FDA" @default.
- NCIT_C81569 NCIT_P329 "798288" @default.
- NCIT_C81569 NCIT_P330 "798288" @default.
- NCIT_C81569 NCIT_P350 "C25H31N2O5.Na" @default.
- NCIT_C81569 NCIT_P366 "Ifetroban_Sodium" @default.
- NCIT_C81569 NCIT_P399 "798288" @default.
- NCIT_C81569 normalizedInformationContent "100" @default.
- NCIT_C81569 referenceCount "1" @default.
- NCIT_C81569 hasExactSynonym "Benzenepropanoic Acid, 2-((3-(4-((Pentylamino)carbonyl)-2-oxazolyl)-7-oxabicyclo(2.2.1)hept-2-yl)methyl)-, Monosodium Salt, (1S-(Exo,Exo))-" @default.
- NCIT_C81569 hasExactSynonym "IFETROBAN SODIUM" @default.
- NCIT_C81569 hasExactSynonym "Ifetroban Sodium" @default.
- NCIT_C81569 inSubset NCIT_C176424 @default.
- NCIT_C81569 inSubset NCIT_C63923 @default.
- NCIT_C81569 type Class @default.
- NCIT_C81569 isDefinedBy ncit.owl @default.
- NCIT_C81569 label "Ifetroban Sodium" @default.
- NCIT_C81569 subClassOf NCIT_C1327 @default.
- NCIT_C81569 subClassOf NCIT_C1908 @default.
- NCIT_C81569 subClassOf NCIT_C1909 @default.
- NCIT_C81569 subClassOf NCIT_C78275 @default.
- NCIT_C81569 subClassOf NCIT_C81569 @default.