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- NCIT_C81570 IAO_0000115 "An orally bioavailable thromboxane (TxA2) and prostaglandin H2 (PGH2) (TP) receptor antagonist, with anti-thrombotic, anti-hypertensive, anti-asthmatic and potential anti-metastatic activities. Upon administration, ifetroban targets and binds to TxA2 and PGH2 receptors, thereby preventing the activity of both TxA2 and PGH2 and disrupting their downstream signaling pathways. This prevents platelet activation, aggregation and thrombosis. It also prevents vascular constriction and causes vasodilation. In addition, as cancer cells use platelets to metastasize to different parts of the body, ifetroban can reduce the stickiness of the platelets and prevent metastasis. TxA2 causes vascular contraction and platelet activation." @default.
- NCIT_C81570 NCIT_A32 NCIT_C1909 @default.
- NCIT_C81570 NCIT_A5 NCIT_C81569 @default.
- NCIT_C81570 NCIT_A7 NCIT_C105093 @default.
- NCIT_C81570 NCIT_NHC0 "C81570" @default.
- NCIT_C81570 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C81570 NCIT_P107 "Ifetroban" @default.
- NCIT_C81570 NCIT_P108 "Ifetroban" @default.
- NCIT_C81570 NCIT_P207 "C0287939" @default.
- NCIT_C81570 NCIT_P210 "143443-90-7" @default.
- NCIT_C81570 NCIT_P319 "E833KT807K" @default.
- NCIT_C81570 NCIT_P322 "CTRP" @default.
- NCIT_C81570 NCIT_P322 "FDA" @default.
- NCIT_C81570 NCIT_P322 "GDC" @default.
- NCIT_C81570 NCIT_P350 "C25H32N2O5" @default.
- NCIT_C81570 NCIT_P366 "Ifetroban" @default.
- NCIT_C81570 NCIT_P375 "Ifetroban" @default.
- NCIT_C81570 normalizedInformationContent "100" @default.
- NCIT_C81570 referenceCount "1" @default.
- NCIT_C81570 hasExactSynonym "IFETROBAN" @default.
- NCIT_C81570 hasExactSynonym "Ifetroban" @default.
- NCIT_C81570 inSubset NCIT_C116977 @default.
- NCIT_C81570 inSubset NCIT_C116978 @default.
- NCIT_C81570 inSubset NCIT_C128784 @default.
- NCIT_C81570 inSubset NCIT_C157711 @default.
- NCIT_C81570 inSubset NCIT_C157712 @default.
- NCIT_C81570 inSubset NCIT_C177537 @default.
- NCIT_C81570 inSubset NCIT_C63923 @default.
- NCIT_C81570 type Class @default.
- NCIT_C81570 isDefinedBy ncit.owl @default.
- NCIT_C81570 label "Ifetroban" @default.
- NCIT_C81570 subClassOf NCIT_C1327 @default.
- NCIT_C81570 subClassOf NCIT_C1908 @default.
- NCIT_C81570 subClassOf NCIT_C1909 @default.
- NCIT_C81570 subClassOf NCIT_C78275 @default.
- NCIT_C81570 subClassOf NCIT_C81570 @default.