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- NCIT_C81615 IAO_0000115 "A 1,5-benzodiazepine and partial gamma-aminobutyric acid (GABA) receptor agonist, with anxiolytic, sedative, and anticonvulsant activities. Clobazam binds to a specific site, distinct from the inhibitory neurotransmitter GABA binding site, on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the opening of chloride-channels. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and a decrease in neuronal excitability." @default.
- NCIT_C81615 NCIT_NHC0 "C81615" @default.
- NCIT_C81615 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C81615 NCIT_P108 "Clobazam" @default.
- NCIT_C81615 NCIT_P207 "C0055891" @default.
- NCIT_C81615 NCIT_P210 "22316-47-8" @default.
- NCIT_C81615 NCIT_P302 "Lennox-Gastaut Syndrome" @default.
- NCIT_C81615 NCIT_P319 "2MRO291B4U" @default.
- NCIT_C81615 NCIT_P322 "FDA" @default.
- NCIT_C81615 NCIT_P350 "C16H13ClN2O2" @default.
- NCIT_C81615 NCIT_P366 "Clobazam" @default.
- NCIT_C81615 NCIT_P368 "CHEBI:31413" @default.
- NCIT_C81615 normalizedInformationContent "100" @default.
- NCIT_C81615 referenceCount "1" @default.
- NCIT_C81615 hasExactSynonym "CLOBAZAM" @default.
- NCIT_C81615 hasExactSynonym "Clobazam" @default.
- NCIT_C81615 hasExactSynonym "Frisium" @default.
- NCIT_C81615 hasExactSynonym "Onfi" @default.
- NCIT_C81615 hasExactSynonym "Urbanol" @default.
- NCIT_C81615 inSubset NCIT_C63923 @default.
- NCIT_C81615 type Class @default.
- NCIT_C81615 isDefinedBy ncit.owl @default.
- NCIT_C81615 label "Clobazam" @default.
- NCIT_C81615 subClassOf NCIT_C1908 @default.
- NCIT_C81615 subClassOf NCIT_C1909 @default.
- NCIT_C81615 subClassOf NCIT_C28197 @default.
- NCIT_C81615 subClassOf NCIT_C78272 @default.
- NCIT_C81615 subClassOf NCIT_C81615 @default.