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- NCIT_C817 IAO_0000115 "The sodium salt form of ceftriaxone, a beta-lactam, third-generation cephalosporin antibiotic with bactericidal activity. Ceftriaxone binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. Compared to the second and first generation cephalosporins, ceftriaxone is more active against gram-negative bacteria and less active against gram-positive bacteria. Ceftriaxone also crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system (CNS)." @default.
- NCIT_C817 NCIT_A6 NCIT_C62020 @default.
- NCIT_C817 NCIT_NHC0 "C817" @default.
- NCIT_C817 NCIT_P106 "Antibiotic" @default.
- NCIT_C817 NCIT_P106 "Organic Chemical" @default.
- NCIT_C817 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C817 NCIT_P108 "Ceftriaxone Sodium" @default.
- NCIT_C817 NCIT_P207 "C0035750" @default.
- NCIT_C817 NCIT_P210 "104376-79-6" @default.
- NCIT_C817 NCIT_P319 "023Z5BR09K" @default.
- NCIT_C817 NCIT_P322 "FDA" @default.
- NCIT_C817 NCIT_P329 "41088" @default.
- NCIT_C817 NCIT_P330 "41088" @default.
- NCIT_C817 NCIT_P350 "2C18H16N8O7S3.4Na.7H2O" @default.
- NCIT_C817 NCIT_P366 "Ceftriaxone" @default.
- NCIT_C817 NCIT_P399 "41088" @default.
- NCIT_C817 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C817 referenceCount "2" @default.
- NCIT_C817 hasExactSynonym "CEFTRIAXONE SODIUM" @default.
- NCIT_C817 hasExactSynonym "Ceftriaxone Sodium" @default.
- NCIT_C817 hasExactSynonym "Rocephin" @default.
- NCIT_C817 inSubset NCIT_C176424 @default.
- NCIT_C817 inSubset NCIT_C63923 @default.
- NCIT_C817 type Class @default.
- NCIT_C817 isDefinedBy ncit.owl @default.
- NCIT_C817 label "Ceftriaxone Sodium" @default.
- NCIT_C817 subClassOf NCIT_C1908 @default.
- NCIT_C817 subClassOf NCIT_C1909 @default.
- NCIT_C817 subClassOf NCIT_C254 @default.
- NCIT_C817 subClassOf NCIT_C258 @default.
- NCIT_C817 subClassOf NCIT_C260 @default.
- NCIT_C817 subClassOf NCIT_C357 @default.
- NCIT_C817 subClassOf NCIT_C817 @default.