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- NCIT_C81941 IAO_0000115 "An orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor prodrug, with potential antiserotonergic activity. Upon administration, telotristat etiprate is converted to its active moiety, telotristat (LP-778902), which binds to and blocks the activity of TPH. This may result in a reduction in peripheral serotonin (5-HT) production and improvement of serotonin-mediated gastrointestinal effects such as severe diarrhea. TPH, the rate-limiting enzyme in serotonin biosynthesis, is overexpressed in carcinoid tumor cells." @default.
- NCIT_C81941 NCIT_A7 NCIT_C105873 @default.
- NCIT_C81941 NCIT_NHC0 "C81941" @default.
- NCIT_C81941 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C81941 NCIT_P107 "Telotristat Etiprate" @default.
- NCIT_C81941 NCIT_P108 "Telotristat Etiprate" @default.
- NCIT_C81941 NCIT_P208 "CL1773665" @default.
- NCIT_C81941 NCIT_P210 "1137608-69-5" @default.
- NCIT_C81941 NCIT_P302 "Carcinoid Syndrome, Ulcerative Colitis" @default.
- NCIT_C81941 NCIT_P319 "3T25U84H4U" @default.
- NCIT_C81941 NCIT_P322 "CTRP" @default.
- NCIT_C81941 NCIT_P322 "FDA" @default.
- NCIT_C81941 NCIT_P329 "639514" @default.
- NCIT_C81941 NCIT_P330 "639514" @default.
- NCIT_C81941 NCIT_P350 "C27H26ClF3N6O3.C9H9NO3" @default.
- NCIT_C81941 NCIT_P366 "TPH_Inhibitor_LX1032" @default.
- NCIT_C81941 NCIT_P399 "639514" @default.
- NCIT_C81941 normalizedInformationContent "100" @default.
- NCIT_C81941 referenceCount "1" @default.
- NCIT_C81941 hasExactSynonym "Ethyl 4-(2-amino-6-((1r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pryrimidin-4-yl)-l-phenylalaninate N-benzoylglycinate (1:1)" @default.
- NCIT_C81941 hasExactSynonym "LX1032 Hippurate" @default.
- NCIT_C81941 hasExactSynonym "LX1606 Hippurate" @default.
- NCIT_C81941 hasExactSynonym "TELOTRISTAT ETIPRATE" @default.
- NCIT_C81941 hasExactSynonym "Telotristat Etiprate" @default.
- NCIT_C81941 hasExactSynonym "Xermelo" @default.
- NCIT_C81941 inSubset NCIT_C116977 @default.
- NCIT_C81941 inSubset NCIT_C116978 @default.
- NCIT_C81941 inSubset NCIT_C176424 @default.
- NCIT_C81941 inSubset NCIT_C63923 @default.
- NCIT_C81941 type Class @default.
- NCIT_C81941 isDefinedBy ncit.owl @default.
- NCIT_C81941 label "Telotristat Etiprate" @default.
- NCIT_C81941 subClassOf NCIT_C1908 @default.
- NCIT_C81941 subClassOf NCIT_C1909 @default.
- NCIT_C81941 subClassOf NCIT_C471 @default.
- NCIT_C81941 subClassOf NCIT_C81941 @default.