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- NCIT_C82218 IAO_0000115 "A non-thiol angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, zabicipril is rapidly converted in vivo by de-esterification into its active form zabiciprilat. Zabiciprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Zabiciprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow." @default.
- NCIT_C82218 NCIT_NHC0 "C82218" @default.
- NCIT_C82218 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82218 NCIT_P108 "Zabicipril" @default.
- NCIT_C82218 NCIT_P207 "C0085048" @default.
- NCIT_C82218 NCIT_P210 "83059-56-7" @default.
- NCIT_C82218 NCIT_P319 "475035SS4C" @default.
- NCIT_C82218 NCIT_P322 "FDA" @default.
- NCIT_C82218 NCIT_P350 "C23H32N2O5" @default.
- NCIT_C82218 NCIT_P366 "Zabicipril" @default.
- NCIT_C82218 normalizedInformationContent "100" @default.
- NCIT_C82218 referenceCount "1" @default.
- NCIT_C82218 hasExactSynonym "(3S)-2-((2S)-N-((1S)-1-Carboxy-3-phenylpropyl)alanyl)-2-azabicyclo(2.2.2)octane-3-carboxylic Acid, 1-ethyl Ester" @default.
- NCIT_C82218 hasExactSynonym "ZABICIPRIL" @default.
- NCIT_C82218 hasExactSynonym "Zabicipril" @default.
- NCIT_C82218 inSubset NCIT_C63923 @default.
- NCIT_C82218 type Class @default.
- NCIT_C82218 isDefinedBy ncit.owl @default.
- NCIT_C82218 label "Zabicipril" @default.
- NCIT_C82218 subClassOf NCIT_C1908 @default.
- NCIT_C82218 subClassOf NCIT_C1909 @default.
- NCIT_C82218 subClassOf NCIT_C247 @default.
- NCIT_C82218 subClassOf NCIT_C270 @default.
- NCIT_C82218 subClassOf NCIT_C471 @default.
- NCIT_C82218 subClassOf NCIT_C78274 @default.
- NCIT_C82218 subClassOf NCIT_C783 @default.
- NCIT_C82218 subClassOf NCIT_C82218 @default.