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- NCIT_C82220 IAO_0000115 "The calcium salt of zofenopril, a sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, zofenopril is hydrolyzed in vivo into its active form zofenoprilat. Zofenoprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Zofenoprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow." @default.
- NCIT_C82220 NCIT_NHC0 "C82220" @default.
- NCIT_C82220 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82220 NCIT_P108 "Zofenopril Calcium" @default.
- NCIT_C82220 NCIT_P207 "C0873162" @default.
- NCIT_C82220 NCIT_P210 "81938-43-4" @default.
- NCIT_C82220 NCIT_P319 "88ZQ329PU2" @default.
- NCIT_C82220 NCIT_P322 "FDA" @default.
- NCIT_C82220 NCIT_P350 "2C22H22NO4S2.Ca" @default.
- NCIT_C82220 NCIT_P366 "Zofenopril_Calcium" @default.
- NCIT_C82220 normalizedInformationContent "100" @default.
- NCIT_C82220 referenceCount "1" @default.
- NCIT_C82220 hasExactSynonym "ZOFENOPRIL CALCIUM" @default.
- NCIT_C82220 hasExactSynonym "Zofenopril Calcium" @default.
- NCIT_C82220 inSubset NCIT_C63923 @default.
- NCIT_C82220 type Class @default.
- NCIT_C82220 isDefinedBy ncit.owl @default.
- NCIT_C82220 label "Zofenopril Calcium" @default.
- NCIT_C82220 subClassOf NCIT_C1908 @default.
- NCIT_C82220 subClassOf NCIT_C1909 @default.
- NCIT_C82220 subClassOf NCIT_C247 @default.
- NCIT_C82220 subClassOf NCIT_C270 @default.
- NCIT_C82220 subClassOf NCIT_C471 @default.
- NCIT_C82220 subClassOf NCIT_C78274 @default.
- NCIT_C82220 subClassOf NCIT_C783 @default.
- NCIT_C82220 subClassOf NCIT_C82220 @default.