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- NCIT_C82349 IAO_0000115 "A small-molecule inhibitor of Aurora kinases A, B and C with potential antineoplastic activity. Aurora kinase inhibitor AMG 900 selectively binds to and inhibits the activities of Aurora kinases A, B and C, which may result in inhibition of cellular division and proliferation in tumor cells that overexpress these kinases. Aurora kinases are serine-threonine kinases that play essential roles in mitotic checkpoint control during mitosis and are overexpressed by a wide variety of cancer cell types." @default.
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- NCIT_C82349 NCIT_NHC0 "C82349" @default.
- NCIT_C82349 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82349 NCIT_P107 "Aurora Kinase Inhibitor AMG 900" @default.
- NCIT_C82349 NCIT_P108 "Aurora Kinase Inhibitor AMG 900" @default.
- NCIT_C82349 NCIT_P207 "C2830045" @default.
- NCIT_C82349 NCIT_P210 "945595-80-2" @default.
- NCIT_C82349 NCIT_P319 "9R2G075611" @default.
- NCIT_C82349 NCIT_P322 "CTRP" @default.
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- NCIT_C82349 NCIT_P329 "639524" @default.
- NCIT_C82349 NCIT_P330 "639524" @default.
- NCIT_C82349 NCIT_P366 "Aurora_Kinase_Inhibitor_AMG_900" @default.
- NCIT_C82349 NCIT_P375 "Aurora Kinase Inhibitor AMG 900" @default.
- NCIT_C82349 NCIT_P399 "639524" @default.
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- NCIT_C82349 normalizedInformationContent "100" @default.
- NCIT_C82349 referenceCount "1" @default.
- NCIT_C82349 hasExactSynonym "AMG 900" @default.
- NCIT_C82349 hasExactSynonym "AMG-900" @default.
- NCIT_C82349 hasExactSynonym "Aurora Kinase Inhibitor AMG 900" @default.
- NCIT_C82349 hasExactSynonym "N-(4-(3-(2-Aminopyrimidin-4-yl)pyridin-2-yloxy)phenyl)-4-(4-methylthiophen-2-yl)phthalazin-1-amine" @default.
- NCIT_C82349 inSubset NCIT_C116977 @default.
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- NCIT_C82349 inSubset NCIT_C177537 @default.
- NCIT_C82349 inSubset NCIT_C63923 @default.
- NCIT_C82349 type Class @default.
- NCIT_C82349 isDefinedBy ncit.owl @default.
- NCIT_C82349 label "Aurora Kinase Inhibitor AMG 900" @default.
- NCIT_C82349 subClassOf B09a8a6177a204cf8849cf762ecda8e7f @default.
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- NCIT_C82349 subClassOf NCIT_C62556 @default.
- NCIT_C82349 subClassOf NCIT_C82349 @default.