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- NCIT_C82361 IAO_0000115 "A genetically-modified autologous dendritic cell-based vaccine expressing a drug-inducible costimulatory CD40 receptor (iCD40) with potential immunomodulating and antineoplastic activities. Autologous dendritic cells (DCs) are genetically modified to express the iCD40 receptor and are pulsed with the tumor antigen prostate-specific membrane antigen (PSMA). Upon intradermal administration, these DCs accumulate in local draining lymph nodes. Twenty-four hours after vaccination, the dimerizer agent AP1903 is administered; AP1903 binds to and activates iCD40 receptors presented on DC surfaces, thus activating the DCs and stimulating a cytotoxic T-lymphocyte (CTL) response against host tumor cells that express PSMA. This delayed activation strategy optimizes DC accumulation in local draining lymph nodes prior to DC activation. iCD40 contains a membrane-localized cytoplasmic CD40 domain fused to a drug-binding domain." @default.
- NCIT_C82361 NCIT_A32 NCIT_C1909 @default.
- NCIT_C82361 NCIT_NHC0 "C82361" @default.
- NCIT_C82361 NCIT_P106 "Cell" @default.
- NCIT_C82361 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82361 NCIT_P108 "Autologous Prostate Cancer Antigen-expressing Dendritic Cell Vaccine BPX-101" @default.
- NCIT_C82361 NCIT_P208 "CL408640" @default.
- NCIT_C82361 NCIT_P322 "GDC" @default.
- NCIT_C82361 NCIT_P329 "640422" @default.
- NCIT_C82361 NCIT_P330 "640422" @default.
- NCIT_C82361 NCIT_P366 "iCD40_Receptor_Pulsed_Autologous_Dendritic_Cell_Vaccine_BP-GMAX-CD1" @default.
- NCIT_C82361 NCIT_P375 "Autologous Prostate Cancer Antigen-expressing Dendritic Cell Vaccine BPX-101" @default.
- NCIT_C82361 NCIT_P399 "640422" @default.
- NCIT_C82361 normalizedInformationContent "100" @default.
- NCIT_C82361 referenceCount "1" @default.
- NCIT_C82361 hasExactSynonym "Autologous Prostate Cancer Antigen-expressing Dendritic Cell Vaccine BPX-101" @default.
- NCIT_C82361 hasExactSynonym "BP-GMAX-CD1" @default.
- NCIT_C82361 hasExactSynonym "BPX-101" @default.
- NCIT_C82361 inSubset NCIT_C128784 @default.
- NCIT_C82361 inSubset NCIT_C157711 @default.
- NCIT_C82361 inSubset NCIT_C157712 @default.
- NCIT_C82361 inSubset NCIT_C176424 @default.
- NCIT_C82361 inSubset NCIT_C177537 @default.
- NCIT_C82361 type Class @default.
- NCIT_C82361 isDefinedBy ncit.owl @default.
- NCIT_C82361 label "Autologous Prostate Cancer Antigen-expressing Dendritic Cell Vaccine BPX-101" @default.
- NCIT_C82361 subClassOf NCIT_C129820 @default.
- NCIT_C82361 subClassOf NCIT_C1663 @default.
- NCIT_C82361 subClassOf NCIT_C1908 @default.
- NCIT_C82361 subClassOf NCIT_C1909 @default.
- NCIT_C82361 subClassOf NCIT_C274 @default.
- NCIT_C82361 subClassOf NCIT_C28308 @default.
- NCIT_C82361 subClassOf NCIT_C28310 @default.
- NCIT_C82361 subClassOf NCIT_C307 @default.
- NCIT_C82361 subClassOf NCIT_C308 @default.
- NCIT_C82361 subClassOf NCIT_C82361 @default.
- NCIT_C82361 subClassOf NCIT_C923 @default.