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- NCIT_C82375 IAO_0000115 "An immunotoxin consisting of two scFv ligands recognizing human CD19 and CD22 linked to the first 389 amino acids of diphtheria toxin (DT), DT 390, with potential antineoplastic activity. The VH and VL regions of anti-CD22 (sFv) and anti-CD19 are reversed and linked by an aggregration stabilizing linker (ARL) consisting of a 20 amino acid segment of human muscle aldolase (hma) and an Xho1-compatible restriction site; the CDR3 region of the VH of anti-CD22 sFv is mutated to enhance its affinity. The anti-CD19 and anti CD-22 portions of the immunotoxin specifically bind to CD19 and CD22 receptors on tumor B cells. Upon internalization, DT catalyzes ADP ribosylation of elongation factor 2 (EF-2) which may result in the irreversible inhibition of protein synthesis and cell death in CD19- and CD22-expressing tumor cells. CD19 and CD22 are transmembrane proteins upregulated on malignant B cells." @default.
- NCIT_C82375 NCIT_A32 NCIT_C1909 @default.
- NCIT_C82375 NCIT_A7 NCIT_C38894 @default.
- NCIT_C82375 NCIT_NHC0 "C82375" @default.
- NCIT_C82375 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C82375 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C82375 NCIT_P107 "Anti-CD19/Anti-CD22 Bispecific Immunotoxin DT2219ARL" @default.
- NCIT_C82375 NCIT_P108 "Anti-CD19/Anti-CD22 Bispecific Immunotoxin DT2219ARL" @default.
- NCIT_C82375 NCIT_P208 "CL408648" @default.
- NCIT_C82375 NCIT_P322 "CTRP" @default.
- NCIT_C82375 NCIT_P322 "GDC" @default.
- NCIT_C82375 NCIT_P325 "A substance being studied in the treatment of some types of B-cell cancer. It contains an antibody linked to a toxic substance. The antibody binds to proteins called CD19 and CD22 on the surface of B cells, and the toxic substance kills the cells. It is a type of bispecific ligand-directed toxin." @default.
- NCIT_C82375 NCIT_P329 "641179" @default.
- NCIT_C82375 NCIT_P330 "641179" @default.
- NCIT_C82375 NCIT_P366 "Anti-CD19_Anti-CD22_Bispecific_Immunotoxin_DT2219ARL" @default.
- NCIT_C82375 NCIT_P375 "Anti-CD19/Anti-CD22 Bispecific Immunotoxin DT2219ARL" @default.
- NCIT_C82375 NCIT_P399 "641179" @default.
- NCIT_C82375 normalizedInformationContent "100" @default.
- NCIT_C82375 referenceCount "1" @default.
- NCIT_C82375 hasExactSynonym "Anti-CD19/Anti-CD22 Bispecific Immunotoxin DT2219ARL" @default.
- NCIT_C82375 hasExactSynonym "Anti-CD19/CD22 BLT DT2219ARL" @default.
- NCIT_C82375 hasExactSynonym "DT2219ARL immunotoxin" @default.
- NCIT_C82375 hasExactSynonym "DT2219ARL" @default.
- NCIT_C82375 inSubset NCIT_C116977 @default.
- NCIT_C82375 inSubset NCIT_C116978 @default.
- NCIT_C82375 inSubset NCIT_C128784 @default.
- NCIT_C82375 inSubset NCIT_C157711 @default.
- NCIT_C82375 inSubset NCIT_C157712 @default.
- NCIT_C82375 inSubset NCIT_C176424 @default.
- NCIT_C82375 inSubset NCIT_C177537 @default.
- NCIT_C82375 type Class @default.
- NCIT_C82375 isDefinedBy ncit.owl @default.
- NCIT_C82375 label "Anti-CD19/Anti-CD22 Bispecific Immunotoxin DT2219ARL" @default.
- NCIT_C82375 subClassOf NCIT_C1512 @default.
- NCIT_C82375 subClassOf NCIT_C163758 @default.
- NCIT_C82375 subClassOf NCIT_C1908 @default.
- NCIT_C82375 subClassOf NCIT_C1909 @default.
- NCIT_C82375 subClassOf NCIT_C198634 @default.
- NCIT_C82375 subClassOf NCIT_C2002 @default.
- NCIT_C82375 subClassOf NCIT_C2330 @default.
- NCIT_C82375 subClassOf NCIT_C274 @default.
- NCIT_C82375 subClassOf NCIT_C307 @default.
- NCIT_C82375 subClassOf NCIT_C308 @default.
- NCIT_C82375 subClassOf NCIT_C575 @default.
- NCIT_C82375 subClassOf NCIT_C82375 @default.