Matches in Ubergraph for { <http://purl.obolibrary.org/obo/NCIT_C82379> ?p ?o ?g. }
Showing items 1 to 51 of
51
with 100 items per page.
- NCIT_C82379 IAO_0000115 "An orally bioavailable inhibitor of vascular endothelial growth factor receptor (VEGFR) and Tie2 receptor tyrosine kinases with potential antiangiogenic and antineoplastic activities. Pan-VEGFR/Tie2 tyrosine kinase inhibitor CEP-11981 selectively binds to VEGFR and Tie2 receptor tyrosine kinases, which may result in the inhibition of endothelial cell migration, proliferation and survival and the inhibition of tumor cell proliferation and tumor cell death. VEGFR and Tie2 are frequently overexpressed by a variety of tumor cell types and play crucial roles in the regulation of angiogenesis and the maintenance of tumor blood vessels. Tie2 (tyrosine kinase with immunoglobulin-like and EGF-like domains) is activated by angiopoietin-1 (Ang-1)." @default.
- NCIT_C82379 NCIT_A32 NCIT_C1909 @default.
- NCIT_C82379 NCIT_A7 NCIT_C17293 @default.
- NCIT_C82379 NCIT_A7 NCIT_C18488 @default.
- NCIT_C82379 NCIT_NHC0 "C82379" @default.
- NCIT_C82379 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82379 NCIT_P107 "Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981" @default.
- NCIT_C82379 NCIT_P108 "Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981" @default.
- NCIT_C82379 NCIT_P207 "C2830064" @default.
- NCIT_C82379 NCIT_P210 "856691-93-5" @default.
- NCIT_C82379 NCIT_P319 "J8AY0Z4CBP" @default.
- NCIT_C82379 NCIT_P322 "CTRP" @default.
- NCIT_C82379 NCIT_P322 "FDA" @default.
- NCIT_C82379 NCIT_P322 "GDC" @default.
- NCIT_C82379 NCIT_P329 "641461" @default.
- NCIT_C82379 NCIT_P330 "641461" @default.
- NCIT_C82379 NCIT_P366 "Oral_Pan-VEGFR_TIE2_Tyrosine_Kinase_Inhibitor_CEP-11981" @default.
- NCIT_C82379 NCIT_P375 "Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981" @default.
- NCIT_C82379 NCIT_P399 "641461" @default.
- NCIT_C82379 normalizedInformationContent "100" @default.
- NCIT_C82379 referenceCount "1" @default.
- NCIT_C82379 hasExactSynonym "4H-Indazolo(5,4-a)pyrrolo(3,4-C)carbazol-4-one, 2,5,6,11,12,13-Hexahydro-2-methyl-11-(2-methylpropyl)-8-(2-pyrimidinylamino)-" @default.
- NCIT_C82379 hasExactSynonym "BOL-303213X" @default.
- NCIT_C82379 hasExactSynonym "CEP 11981" @default.
- NCIT_C82379 hasExactSynonym "CEP-11981" @default.
- NCIT_C82379 hasExactSynonym "ESK 981" @default.
- NCIT_C82379 hasExactSynonym "ESK-981" @default.
- NCIT_C82379 hasExactSynonym "ESK981" @default.
- NCIT_C82379 hasExactSynonym "Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981" @default.
- NCIT_C82379 inSubset NCIT_C116977 @default.
- NCIT_C82379 inSubset NCIT_C116978 @default.
- NCIT_C82379 inSubset NCIT_C128784 @default.
- NCIT_C82379 inSubset NCIT_C157711 @default.
- NCIT_C82379 inSubset NCIT_C157712 @default.
- NCIT_C82379 inSubset NCIT_C176424 @default.
- NCIT_C82379 inSubset NCIT_C177537 @default.
- NCIT_C82379 inSubset NCIT_C63923 @default.
- NCIT_C82379 type Class @default.
- NCIT_C82379 isDefinedBy ncit.owl @default.
- NCIT_C82379 label "Pan-VEGFR/TIE2 Tyrosine Kinase Inhibitor CEP-11981" @default.
- NCIT_C82379 subClassOf NCIT_C129824 @default.
- NCIT_C82379 subClassOf NCIT_C129825 @default.
- NCIT_C82379 subClassOf NCIT_C1404 @default.
- NCIT_C82379 subClassOf NCIT_C1742 @default.
- NCIT_C82379 subClassOf NCIT_C1908 @default.
- NCIT_C82379 subClassOf NCIT_C1909 @default.
- NCIT_C82379 subClassOf NCIT_C1967 @default.
- NCIT_C82379 subClassOf NCIT_C2189 @default.
- NCIT_C82379 subClassOf NCIT_C274 @default.
- NCIT_C82379 subClassOf NCIT_C471 @default.
- NCIT_C82379 subClassOf NCIT_C82379 @default.