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- NCIT_C82380 IAO_0000115 "The orally bioavailable bismesylate salt of pictilisib, a small molecule inhibitor of class I phosphatidylinositol 3 kinase (PI3K), with potential antineoplastic activity. Upon administration, pictilisib selectively binds to PI3K in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway. This may result in inhibition of tumor cell growth, motility and survival in susceptible tumor cell populations. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis; dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents." @default.
- NCIT_C82380 NCIT_A32 NCIT_C1909 @default.
- NCIT_C82380 NCIT_A7 NCIT_C17270 @default.
- NCIT_C82380 NCIT_NHC0 "C82380" @default.
- NCIT_C82380 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82380 NCIT_P107 "Pictilisib Bismesylate" @default.
- NCIT_C82380 NCIT_P108 "Pictilisib Bismesylate" @default.
- NCIT_C82380 NCIT_P208 "CL408651" @default.
- NCIT_C82380 NCIT_P210 "957054-33-0" @default.
- NCIT_C82380 NCIT_P319 "G3D7HF2GS9" @default.
- NCIT_C82380 NCIT_P322 "CTRP" @default.
- NCIT_C82380 NCIT_P322 "FDA" @default.
- NCIT_C82380 NCIT_P322 "GDC" @default.
- NCIT_C82380 NCIT_P329 "641462" @default.
- NCIT_C82380 NCIT_P330 "641462" @default.
- NCIT_C82380 NCIT_P366 "PI3K_Inhibitor_GDC-0941_Bismesylate" @default.
- NCIT_C82380 NCIT_P375 "Pictilisib Bismesylate" @default.
- NCIT_C82380 NCIT_P399 "641462" @default.
- NCIT_C82380 normalizedInformationContent "100" @default.
- NCIT_C82380 referenceCount "1" @default.
- NCIT_C82380 hasExactSynonym "2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1- ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, bimesylate salt" @default.
- NCIT_C82380 hasExactSynonym "GDC-0941 Bismesylate" @default.
- NCIT_C82380 hasExactSynonym "GDC-0941 Dimesylate" @default.
- NCIT_C82380 hasExactSynonym "PICTILISIB BISMESYLATE" @default.
- NCIT_C82380 hasExactSynonym "Pictilisib Bismesylate" @default.
- NCIT_C82380 hasExactSynonym "Pictilisib Dimesylate" @default.
- NCIT_C82380 hasExactSynonym "Thieno(3,2-d)pyrimidine, 2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)-1-piperazinyl)methyl)-4-(4-morpholinyl)-, Methanesulfonate (1:2)" @default.
- NCIT_C82380 inSubset NCIT_C116977 @default.
- NCIT_C82380 inSubset NCIT_C116978 @default.
- NCIT_C82380 inSubset NCIT_C128784 @default.
- NCIT_C82380 inSubset NCIT_C157711 @default.
- NCIT_C82380 inSubset NCIT_C157712 @default.
- NCIT_C82380 inSubset NCIT_C176424 @default.
- NCIT_C82380 inSubset NCIT_C177537 @default.
- NCIT_C82380 inSubset NCIT_C63923 @default.
- NCIT_C82380 type Class @default.
- NCIT_C82380 isDefinedBy ncit.owl @default.
- NCIT_C82380 label "Pictilisib Bismesylate" @default.
- NCIT_C82380 subClassOf NCIT_C129824 @default.
- NCIT_C82380 subClassOf NCIT_C129825 @default.
- NCIT_C82380 subClassOf NCIT_C1404 @default.
- NCIT_C82380 subClassOf NCIT_C163758 @default.
- NCIT_C82380 subClassOf NCIT_C1742 @default.
- NCIT_C82380 subClassOf NCIT_C1908 @default.
- NCIT_C82380 subClassOf NCIT_C1909 @default.
- NCIT_C82380 subClassOf NCIT_C2152 @default.
- NCIT_C82380 subClassOf NCIT_C2189 @default.
- NCIT_C82380 subClassOf NCIT_C274 @default.
- NCIT_C82380 subClassOf NCIT_C471 @default.
- NCIT_C82380 subClassOf NCIT_C82380 @default.