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- NCIT_C82386 IAO_0000115 "An orally bioavailable inhibitor of B-raf (BRAF) protein with potential antineoplastic activity. Dabrafenib selectively binds to and inhibits the activity of B-raf, which may inhibit the proliferation of tumor cells which contain a mutated BRAF gene. B-raf belongs to the raf/mil family of serine/threonine protein kinases and plays a role in regulating the MAP kinase/ERKs signaling pathway, which may be constitutively activated due to BRAF gene mutations." @default.
- NCIT_C82386 NCIT_A32 NCIT_C1909 @default.
- NCIT_C82386 NCIT_NHC0 "C82386" @default.
- NCIT_C82386 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82386 NCIT_P107 "Dabrafenib" @default.
- NCIT_C82386 NCIT_P108 "Dabrafenib" @default.
- NCIT_C82386 NCIT_P207 "C3467876" @default.
- NCIT_C82386 NCIT_P210 "1195765-45-7" @default.
- NCIT_C82386 NCIT_P302 "metastatic non-small cell lung cancer (NSCLC) with BRAF V600E mutation" @default.
- NCIT_C82386 NCIT_P319 "QGP4HA4G1B" @default.
- NCIT_C82386 NCIT_P322 "CTRP" @default.
- NCIT_C82386 NCIT_P322 "FDA" @default.
- NCIT_C82386 NCIT_P322 "GDC" @default.
- NCIT_C82386 NCIT_P329 "641977" @default.
- NCIT_C82386 NCIT_P330 "641977" @default.
- NCIT_C82386 NCIT_P350 "C23H20F3N5O2S2" @default.
- NCIT_C82386 NCIT_P366 "BRAF_Inhibitor_GSK2118436" @default.
- NCIT_C82386 NCIT_P375 "Dabrafenib" @default.
- NCIT_C82386 NCIT_P399 "641977" @default.
- NCIT_C82386 normalizedInformationContent "90.826665450122817" @default.
- NCIT_C82386 referenceCount "4" @default.
- NCIT_C82386 hasExactSynonym "BRAF Inhibitor GSK2118436" @default.
- NCIT_C82386 hasExactSynonym "Benzenesulfonamide, N-(3-(5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl)-2-fluorophenyl)-2,6-difluoro-" @default.
- NCIT_C82386 hasExactSynonym "DABRAFENIB" @default.
- NCIT_C82386 hasExactSynonym "Dabrafenib" @default.
- NCIT_C82386 hasExactSynonym "GSK-2118436" @default.
- NCIT_C82386 hasExactSynonym "GSK-2118436A" @default.
- NCIT_C82386 hasExactSynonym "GSK2118436" @default.
- NCIT_C82386 inSubset NCIT_C116977 @default.
- NCIT_C82386 inSubset NCIT_C116978 @default.
- NCIT_C82386 inSubset NCIT_C128784 @default.
- NCIT_C82386 inSubset NCIT_C157711 @default.
- NCIT_C82386 inSubset NCIT_C157712 @default.
- NCIT_C82386 inSubset NCIT_C176424 @default.
- NCIT_C82386 inSubset NCIT_C177537 @default.
- NCIT_C82386 inSubset NCIT_C63923 @default.
- NCIT_C82386 type Class @default.
- NCIT_C82386 isDefinedBy ncit.owl @default.
- NCIT_C82386 label "Dabrafenib" @default.
- NCIT_C82386 subClassOf NCIT_C129824 @default.
- NCIT_C82386 subClassOf NCIT_C129825 @default.
- NCIT_C82386 subClassOf NCIT_C1404 @default.
- NCIT_C82386 subClassOf NCIT_C155322 @default.
- NCIT_C82386 subClassOf NCIT_C163758 @default.
- NCIT_C82386 subClassOf NCIT_C1908 @default.
- NCIT_C82386 subClassOf NCIT_C1909 @default.
- NCIT_C82386 subClassOf NCIT_C2189 @default.
- NCIT_C82386 subClassOf NCIT_C2336 @default.
- NCIT_C82386 subClassOf NCIT_C274 @default.
- NCIT_C82386 subClassOf NCIT_C471 @default.
- NCIT_C82386 subClassOf NCIT_C61074 @default.
- NCIT_C82386 subClassOf NCIT_C82386 @default.