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- NCIT_C82387 IAO_0000115 "An orally bioavailable inhibitor of human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor Hsp990 binds to and inhibits the activity of Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. Hsp90, upregulated in a variety of tumor cells, is a molecular chaperone that plays a key role in the conformational maturation, stability and function of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation and/or immune responses." @default.
- NCIT_C82387 NCIT_A32 NCIT_C1909 @default.
- NCIT_C82387 NCIT_NHC0 "C82387" @default.
- NCIT_C82387 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82387 NCIT_P108 "Hsp90 Inhibitor HSP990" @default.
- NCIT_C82387 NCIT_P208 "CL408658" @default.
- NCIT_C82387 NCIT_P322 "GDC" @default.
- NCIT_C82387 NCIT_P329 "641983" @default.
- NCIT_C82387 NCIT_P330 "641983" @default.
- NCIT_C82387 NCIT_P366 "Oral_Hsp90_Inhibitor_HSP990" @default.
- NCIT_C82387 NCIT_P375 "Hsp90 Inhibitor HSP990" @default.
- NCIT_C82387 NCIT_P399 "641983" @default.
- NCIT_C82387 NCIT_R125 NCIT_C17828 @default.
- NCIT_C82387 NCIT_R125 NCIT_C20150 @default.
- NCIT_C82387 NCIT_R125 NCIT_C20480 @default.
- NCIT_C82387 NCIT_R125 NCIT_C40715 @default.
- NCIT_C82387 NCIT_R125 NCIT_C41515 @default.
- NCIT_C82387 NCIT_R125 NCIT_C51037 @default.
- NCIT_C82387 normalizedInformationContent "100" @default.
- NCIT_C82387 referenceCount "1" @default.
- NCIT_C82387 hasExactSynonym "HSP990" @default.
- NCIT_C82387 hasExactSynonym "Hsp90 Inhibitor HSP990" @default.
- NCIT_C82387 inSubset NCIT_C128784 @default.
- NCIT_C82387 inSubset NCIT_C157711 @default.
- NCIT_C82387 inSubset NCIT_C157712 @default.
- NCIT_C82387 inSubset NCIT_C176424 @default.
- NCIT_C82387 inSubset NCIT_C177537 @default.
- NCIT_C82387 type Class @default.
- NCIT_C82387 isDefinedBy ncit.owl @default.
- NCIT_C82387 label "Hsp90 Inhibitor HSP990" @default.
- NCIT_C82387 subClassOf NCIT_C129824 @default.
- NCIT_C82387 subClassOf NCIT_C156880 @default.
- NCIT_C82387 subClassOf NCIT_C1908 @default.
- NCIT_C82387 subClassOf NCIT_C1909 @default.
- NCIT_C82387 subClassOf NCIT_C2189 @default.
- NCIT_C82387 subClassOf NCIT_C274 @default.
- NCIT_C82387 subClassOf NCIT_C74526 @default.
- NCIT_C82387 subClassOf NCIT_C82387 @default.