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- NCIT_C82389 IAO_0000115 "An orally bioavailable Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor MK1496 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner." @default.
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- NCIT_C82389 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82389 NCIT_P108 "Polo-like Kinase 1 Inhibitor MK1496" @default.
- NCIT_C82389 NCIT_P208 "CL408660" @default.
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- NCIT_C82389 NCIT_P329 "642286" @default.
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- NCIT_C82389 NCIT_P366 "Polo-like_Kinase_1_Inhibitor_MK1496" @default.
- NCIT_C82389 NCIT_P375 "Polo-like Kinase 1 Inhibitor MK1496" @default.
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- NCIT_C82389 referenceCount "1" @default.
- NCIT_C82389 hasExactSynonym "MK1496" @default.
- NCIT_C82389 hasExactSynonym "PLK1 Inhibitor MK1496" @default.
- NCIT_C82389 hasExactSynonym "Polo-like Kinase 1 Inhibitor MK1496" @default.
- NCIT_C82389 inSubset NCIT_C128784 @default.
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- NCIT_C82389 type Class @default.
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- NCIT_C82389 label "Polo-like Kinase 1 Inhibitor MK1496" @default.
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