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- NCIT_C82404 IAO_0000115 "A small-molecule pan-PIM protein kinase inhibitor with potential antineoplastic activity. PIM kinase inhibitor SGI-1776 binds to and inhibits the activities of PIM-1, -2 and -3 serine/threonine kinases, which may result in the interruption of the G1/S phase cell cycle transition, the expression of pro-apoptotic Bcl2 proteins and tumor cell apoptosis. PIM kinases play key roles in cell cycle progression and apoptosis inhibition and may be overexpressed in various malignancies." @default.
- NCIT_C82404 NCIT_A32 NCIT_C1909 @default.
- NCIT_C82404 NCIT_A7 NCIT_C104800 @default.
- NCIT_C82404 NCIT_A7 NCIT_C178145 @default.
- NCIT_C82404 NCIT_A7 NCIT_C18600 @default.
- NCIT_C82404 NCIT_NHC0 "C82404" @default.
- NCIT_C82404 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82404 NCIT_P107 "PIM Kinase Inhibitor SGI-1776" @default.
- NCIT_C82404 NCIT_P108 "PIM Kinase Inhibitor SGI-1776" @default.
- NCIT_C82404 NCIT_P207 "C2742218" @default.
- NCIT_C82404 NCIT_P210 "1025065-69-3" @default.
- NCIT_C82404 NCIT_P319 "72AUA0603W" @default.
- NCIT_C82404 NCIT_P322 "CTRP" @default.
- NCIT_C82404 NCIT_P322 "FDA" @default.
- NCIT_C82404 NCIT_P322 "GDC" @default.
- NCIT_C82404 NCIT_P329 "638088" @default.
- NCIT_C82404 NCIT_P330 "638088" @default.
- NCIT_C82404 NCIT_P366 "Pim_Kinase_Inhibitor_SGI-1776" @default.
- NCIT_C82404 NCIT_P375 "PIM Kinase Inhibitor SGI-1776" @default.
- NCIT_C82404 NCIT_P399 "638088" @default.
- NCIT_C82404 normalizedInformationContent "100" @default.
- NCIT_C82404 referenceCount "1" @default.
- NCIT_C82404 hasExactSynonym "PIM Kinase Inhibitor SGI-1776" @default.
- NCIT_C82404 hasExactSynonym "SGI-1776" @default.
- NCIT_C82404 inSubset NCIT_C116977 @default.
- NCIT_C82404 inSubset NCIT_C116978 @default.
- NCIT_C82404 inSubset NCIT_C128784 @default.
- NCIT_C82404 inSubset NCIT_C157711 @default.
- NCIT_C82404 inSubset NCIT_C157712 @default.
- NCIT_C82404 inSubset NCIT_C176424 @default.
- NCIT_C82404 inSubset NCIT_C177537 @default.
- NCIT_C82404 inSubset NCIT_C63923 @default.
- NCIT_C82404 type Class @default.
- NCIT_C82404 isDefinedBy ncit.owl @default.
- NCIT_C82404 label "PIM Kinase Inhibitor SGI-1776" @default.
- NCIT_C82404 subClassOf NCIT_C129824 @default.
- NCIT_C82404 subClassOf NCIT_C129825 @default.
- NCIT_C82404 subClassOf NCIT_C1404 @default.
- NCIT_C82404 subClassOf NCIT_C1908 @default.
- NCIT_C82404 subClassOf NCIT_C1909 @default.
- NCIT_C82404 subClassOf NCIT_C2189 @default.
- NCIT_C82404 subClassOf NCIT_C274 @default.
- NCIT_C82404 subClassOf NCIT_C471 @default.
- NCIT_C82404 subClassOf NCIT_C61074 @default.
- NCIT_C82404 subClassOf NCIT_C82404 @default.