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- NCIT_C82408 IAO_0000115 "A preparation of autologous human T-lymphocytes isolated from renal cell cancer (RCC) patient and transduced with 2G-1 TCR, a retroviral vector encoding the alpha and beta chains of a T-cell receptor that recognizes TNF-related apoptosis inducing ligand (TRAIL) bound to death receptor 4 (DR4), with potential immunostimulating and antineoplastic activities. After transduction, expansion in culture, and introduction into the RCC patient, 2G-1 TCR retroviral vector-transduced lymphocytes may stimulate a cytotoxic T lymphocyte (CTL) response against RCC cells with TRAIL bound to DR4 on their surfaces. TRAIL, a member of the TNF superfamily, is a homotrimeric type II membrane protein that rapidly induces oligomerization of receptor intracellular death domains and apoptosis in a variety of tumor cells when bound to its receptors; DR4 (TRAIL receptor 1), a member of the TNF receptor family, is overexpressed by a variety of malignant cell types." @default.
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- NCIT_C82408 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82408 NCIT_P108 "2G-1 TCR Retroviral Vector-Transduced Lymphocytes" @default.
- NCIT_C82408 NCIT_P208 "CL408672" @default.
- NCIT_C82408 NCIT_P329 "639521" @default.
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- NCIT_C82408 NCIT_P366 "_2G-1_TCR_Retroviral_Vector-Transduced_Lymphocytes" @default.
- NCIT_C82408 NCIT_P399 "639521" @default.
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- NCIT_C82408 hasExactSynonym "2G-1 TCR Retroviral Vector-Transduced Lymphocytes" @default.
- NCIT_C82408 hasExactSynonym "PG13-A(F/K)-F-SGSG-T2a-B(opt)(2G-1 TCR) Retroviral Vector-Transduced Lymphocytes" @default.
- NCIT_C82408 inSubset NCIT_C128784 @default.
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- NCIT_C82408 type Class @default.
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- NCIT_C82408 label "2G-1 TCR Retroviral Vector-Transduced Lymphocytes" @default.
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