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- NCIT_C82413 IAO_0000115 "An orally active inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor beta (PDGFRb), and the ephrin B4 receptor B4 (EphB4) with potential antiangiogenic and antineoplastic activities. Angiogenesis inhibitor JI-101 binds to and inhibits VEGFR2, PDGFRb and EphB4, which may inhibit tumor angiogenesis and, so, cellular proliferation in tumor cells overexpressing VEGFR2, PDGFRb and EphB4. The receptor tyrosine kinases VEGFR2, PDGFRb and EphB4 may be overexpressed in a number of different cancer cell types and may play crucial roles in tumor angiogenesis." @default.
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- NCIT_C82413 NCIT_NHC0 "C82413" @default.
- NCIT_C82413 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82413 NCIT_P107 "Angiogenesis Inhibitor JI-101" @default.
- NCIT_C82413 NCIT_P108 "Angiogenesis Inhibitor JI-101" @default.
- NCIT_C82413 NCIT_P207 "C2830086" @default.
- NCIT_C82413 NCIT_P210 "900573-88-8" @default.
- NCIT_C82413 NCIT_P319 "980M4N37DH" @default.
- NCIT_C82413 NCIT_P322 "CTRP" @default.
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- NCIT_C82413 NCIT_P329 "637113" @default.
- NCIT_C82413 NCIT_P330 "637113" @default.
- NCIT_C82413 NCIT_P366 "Oral_Angiogenesis_Inhibitor_JI-101" @default.
- NCIT_C82413 NCIT_P375 "Angiogenesis Inhibitor JI-101" @default.
- NCIT_C82413 NCIT_P399 "637113" @default.
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- NCIT_C82413 normalizedInformationContent "100" @default.
- NCIT_C82413 referenceCount "1" @default.
- NCIT_C82413 hasExactSynonym "Angiogenesis Inhibitor JI-101" @default.
- NCIT_C82413 hasExactSynonym "JI-101" @default.
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- NCIT_C82413 type Class @default.
- NCIT_C82413 isDefinedBy ncit.owl @default.
- NCIT_C82413 label "Angiogenesis Inhibitor JI-101" @default.
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