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- NCIT_C82600 IAO_0000115 "A synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. (NCI04)" @default.
- NCIT_C82600 NCIT_A32 NCIT_C1909 @default.
- NCIT_C82600 NCIT_A6 NCIT_C38709 @default.
- NCIT_C82600 NCIT_NHC0 "C82600" @default.
- NCIT_C82600 NCIT_P106 "Organic Chemical" @default.
- NCIT_C82600 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82600 NCIT_P108 "Deslorelin Acetate" @default.
- NCIT_C82600 NCIT_P207 "C0378714" @default.
- NCIT_C82600 NCIT_P210 "82318-06-7" @default.
- NCIT_C82600 NCIT_P319 "679007NR5C" @default.
- NCIT_C82600 NCIT_P322 "FDA" @default.
- NCIT_C82600 NCIT_P322 "GDC" @default.
- NCIT_C82600 NCIT_P329 "357620" @default.
- NCIT_C82600 NCIT_P330 "357620" @default.
- NCIT_C82600 NCIT_P350 "C64H83N17O12.C2H4O2" @default.
- NCIT_C82600 NCIT_P366 "Deslorelin_Acetate" @default.
- NCIT_C82600 NCIT_P375 "Deslorelin Acetate" @default.
- NCIT_C82600 NCIT_P399 "357620" @default.
- NCIT_C82600 normalizedInformationContent "100" @default.
- NCIT_C82600 referenceCount "1" @default.
- NCIT_C82600 hasExactSynonym "5-Oxo-L-Prolyl-L-Histidyl-L-Tryptophyl-L-Seryl-L-Tyrosyl-D-Tryptophyl-L-Leucyl-L-Arginyl-N-Ethyl-L-Prolinamide Acetate" @default.
- NCIT_C82600 hasExactSynonym "6-D-Tryptophan-9-(N-Ethyl-L-Prolinamide)-1-9-Luteinizing Hormone-Releasing Factor (Swine) Acetate" @default.
- NCIT_C82600 hasExactSynonym "DESLORELIN ACETATE" @default.
- NCIT_C82600 hasExactSynonym "Deslorelin Acetate" @default.
- NCIT_C82600 inSubset NCIT_C128784 @default.
- NCIT_C82600 inSubset NCIT_C157711 @default.
- NCIT_C82600 inSubset NCIT_C157712 @default.
- NCIT_C82600 inSubset NCIT_C176424 @default.
- NCIT_C82600 inSubset NCIT_C177537 @default.
- NCIT_C82600 inSubset NCIT_C63923 @default.
- NCIT_C82600 type Class @default.
- NCIT_C82600 isDefinedBy ncit.owl @default.
- NCIT_C82600 label "Deslorelin Acetate" @default.
- NCIT_C82600 subClassOf NCIT_C147908 @default.
- NCIT_C82600 subClassOf NCIT_C1908 @default.
- NCIT_C82600 subClassOf NCIT_C1909 @default.
- NCIT_C82600 subClassOf NCIT_C1910 @default.
- NCIT_C82600 subClassOf NCIT_C548 @default.
- NCIT_C82600 subClassOf NCIT_C82600 @default.