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- NCIT_C82623 IAO_0000115 "An injectable formulation of a neurotoxin derived through the fermentation of the Hall strain of Clostridium botulinum type A with neuromuscular transmission inhibitory and analgesic activities. Upon injection into the affected muscle, the heavy chain portion of botulinum toxin type A (BTX-A) binds to the cell membrane of the motor nerve and is internalized via endocytosis. Upon entry, the light chain portion of the toxin is activated and cleaves the protein SNAP-25, thereby preventing the fusion of acetylcholine (ACh)-containing synaptic vesicles with the cell membrane and, so, the release of ACh into the neuromuscular junction; subsequent binding of ACH to motor end-plate nicotinic acid receptors and ACh-mediated muscle contraction are thus blocked. In addition to ACh, BTX-A may inhibit the release of neuropeptides, such as substance P and glutamate, which may contribute to its analgesic activity." @default.
- NCIT_C82623 NCIT_NHC0 "C82623" @default.
- NCIT_C82623 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C82623 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82623 NCIT_P107 "Botulinum Toxin Type A" @default.
- NCIT_C82623 NCIT_P108 "Botulinum Toxin Type A" @default.
- NCIT_C82623 NCIT_P207 "C0006050" @default.
- NCIT_C82623 NCIT_P210 "93384-43-1" @default.
- NCIT_C82623 NCIT_P302 "Treatment of cervical dystonia, severe primary axillary hyperhidrosis, Glabellar lines, blepharospasm, strabismus" @default.
- NCIT_C82623 NCIT_P319 "E211KPY694" @default.
- NCIT_C82623 NCIT_P322 "CTRP" @default.
- NCIT_C82623 NCIT_P322 "FDA" @default.
- NCIT_C82623 NCIT_P325 "A drug used to treat certain medical conditions. These include severe underarm sweating and severe muscle spasms in the neck and shoulders. OnabotulinumtoxinA is also used to smooth wrinkles on the face. It is being studied in the treatment of pain in patients with skin leiomyomas (benign smooth muscle tumors) and other conditions. It is a form of a toxin made by the bacterium Clostridium botulinum.." @default.
- NCIT_C82623 NCIT_P325 "A toxin made by the bacterium Clostridium botulinum. It can cause food poisoning. The drug Botox is a form of the toxin that can be used in small amounts to treat certain medical conditions. These include severe underarm sweating and severe muscle spasms in the neck and shoulders. Botulinum toxin type A is also used to smooth wrinkles on the face. It is being studied in the treatment of pain in patients with skin leiomyomas (benign smooth muscle tumors) and other conditions." @default.
- NCIT_C82623 NCIT_P329 "634923" @default.
- NCIT_C82623 NCIT_P330 "634923" @default.
- NCIT_C82623 NCIT_P366 "Botulinum_Toxin_Type_A" @default.
- NCIT_C82623 NCIT_P399 "634923" @default.
- NCIT_C82623 normalizedInformationContent "84.76342111748103" @default.
- NCIT_C82623 referenceCount "10" @default.
- NCIT_C82623 hasExactSynonym "AbobotulinumtoxinA" @default.
- NCIT_C82623 hasExactSynonym "BOTULINUM TOXIN TYPE A" @default.
- NCIT_C82623 hasExactSynonym "BTX-A" @default.
- NCIT_C82623 hasExactSynonym "Botox Cosmetic" @default.
- NCIT_C82623 hasExactSynonym "Botox" @default.
- NCIT_C82623 hasExactSynonym "Botulinum A Toxin" @default.
- NCIT_C82623 hasExactSynonym "Botulinum Neurotoxin Type A" @default.
- NCIT_C82623 hasExactSynonym "Botulinum Toxin A" @default.
- NCIT_C82623 hasExactSynonym "Botulinum Toxin Type A" @default.
- NCIT_C82623 hasExactSynonym "DaxibotulinumtoxinA" @default.
- NCIT_C82623 hasExactSynonym "Dysport" @default.
- NCIT_C82623 hasExactSynonym "EvabotulinumtoxinA" @default.
- NCIT_C82623 hasExactSynonym "IncobotulinumtoxinA" @default.
- NCIT_C82623 hasExactSynonym "OnabotulinumtoxinA" @default.
- NCIT_C82623 hasExactSynonym "Onaclostox" @default.
- NCIT_C82623 hasExactSynonym "Xeomin" @default.
- NCIT_C82623 hasExactSynonym "botulinum toxin A" @default.
- NCIT_C82623 hasExactSynonym "onabotulinumtoxinA" @default.
- NCIT_C82623 inSubset NCIT_C116977 @default.
- NCIT_C82623 inSubset NCIT_C116978 @default.
- NCIT_C82623 inSubset NCIT_C176424 @default.
- NCIT_C82623 inSubset NCIT_C63923 @default.
- NCIT_C82623 type Class @default.
- NCIT_C82623 isDefinedBy ncit.owl @default.
- NCIT_C82623 label "Botulinum Toxin Type A" @default.
- NCIT_C82623 subClassOf NCIT_C163032 @default.
- NCIT_C82623 subClassOf NCIT_C1908 @default.
- NCIT_C82623 subClassOf NCIT_C1932 @default.
- NCIT_C82623 subClassOf NCIT_C296 @default.
- NCIT_C82623 subClassOf NCIT_C82623 @default.
- NCIT_C82623 subClassOf NCIT_C894 @default.