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- NCIT_C82660 IAO_0000115 "An enteric-coated orally bioavailable formulation of the hydrochloride salt of a small-molecule agonist for transient receptor potential melastatin member 8 (TRPM8 or Trp-p8) with potential antineoplastic activity. The active ingredient in enteric-coated TRPM8 agonist D-3263 hydrochloride binds to and activates TRPM8, which may result in an increase in calcium and sodium entry; the disruption of calcium and sodium homeostasis; and the induction of cell death in TRPM8-expressing tumor cells. This agent may decrease dihydrotestosterone (DHT) levels, which may contribute to its inhibitory effects on prostate cancer and BPH. TRPM8 is a transmembrane calcium channel protein that is normally expressed in prostate cells and appears to be overexpressed in benign prostatic hyperplasia (BPH) and in prostate cancer." @default.
- NCIT_C82660 NCIT_A32 NCIT_C1909 @default.
- NCIT_C82660 NCIT_NHC0 "C82660" @default.
- NCIT_C82660 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82660 NCIT_P108 "Enteric-Coated TRPM8 Agonist D-3263 Hydrochloride" @default.
- NCIT_C82660 NCIT_P208 "CL411370" @default.
- NCIT_C82660 NCIT_P210 "1008763-54-9" @default.
- NCIT_C82660 NCIT_P319 "R82GTC01OB" @default.
- NCIT_C82660 NCIT_P322 "FDA" @default.
- NCIT_C82660 NCIT_P322 "GDC" @default.
- NCIT_C82660 NCIT_P329 "636649" @default.
- NCIT_C82660 NCIT_P330 "636649" @default.
- NCIT_C82660 NCIT_P366 "Enteric-Coated_TRPM8_Agonist_D-3263_Hydrochloride" @default.
- NCIT_C82660 NCIT_P375 "Enteric-Coated TRPM8 Agonist D-3263 Hydrochloride" @default.
- NCIT_C82660 NCIT_P399 "636649" @default.
- NCIT_C82660 normalizedInformationContent "100" @default.
- NCIT_C82660 referenceCount "1" @default.
- NCIT_C82660 hasExactSynonym "D-3263 HYDROCHLORIDE" @default.
- NCIT_C82660 hasExactSynonym "EC D-3263 HCl" @default.
- NCIT_C82660 hasExactSynonym "EC D-3263 Hydrochloride" @default.
- NCIT_C82660 hasExactSynonym "Enteric-Coated TRPM8 Agonist D-3263 Hydrochloride" @default.
- NCIT_C82660 inSubset NCIT_C128784 @default.
- NCIT_C82660 inSubset NCIT_C157711 @default.
- NCIT_C82660 inSubset NCIT_C157712 @default.
- NCIT_C82660 inSubset NCIT_C176424 @default.
- NCIT_C82660 inSubset NCIT_C177537 @default.
- NCIT_C82660 inSubset NCIT_C63923 @default.
- NCIT_C82660 type Class @default.
- NCIT_C82660 isDefinedBy ncit.owl @default.
- NCIT_C82660 label "Enteric-Coated TRPM8 Agonist D-3263 Hydrochloride" @default.
- NCIT_C82660 subClassOf NCIT_C1908 @default.
- NCIT_C82660 subClassOf NCIT_C1909 @default.
- NCIT_C82660 subClassOf NCIT_C2196 @default.
- NCIT_C82660 subClassOf NCIT_C274 @default.
- NCIT_C82660 subClassOf NCIT_C82660 @default.