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- NCIT_C82676 IAO_0000115 "A liposomal formulation of the semisynthetic camptothecin analogue irinotecan with potential antineoplastic activity. During the S phase of the cell cycle, irinotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Liposome encapsulation of this agent promotes efficient drug delivery into the cytosol from the endosome compartment of the cell." @default.
- NCIT_C82676 NCIT_A32 NCIT_C1909 @default.
- NCIT_C82676 NCIT_A7 NCIT_C16516 @default.
- NCIT_C82676 NCIT_NHC0 "C82676" @default.
- NCIT_C82676 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82676 NCIT_P107 "Irinotecan Sucrosofate" @default.
- NCIT_C82676 NCIT_P108 "Irinotecan Sucrosofate" @default.
- NCIT_C82676 NCIT_P207 "C4057931" @default.
- NCIT_C82676 NCIT_P210 "1361317-83-0" @default.
- NCIT_C82676 NCIT_P302 "metastatic adenocarcinoma of the pancreas" @default.
- NCIT_C82676 NCIT_P319 "OL741S3N8B" @default.
- NCIT_C82676 NCIT_P322 "CTRP" @default.
- NCIT_C82676 NCIT_P322 "FDA" @default.
- NCIT_C82676 NCIT_P322 "GDC" @default.
- NCIT_C82676 NCIT_P329 "632436" @default.
- NCIT_C82676 NCIT_P330 "632436" @default.
- NCIT_C82676 NCIT_P366 "Liposome-Encapsulated_Irinotecan_Hydrochloride_PEP02" @default.
- NCIT_C82676 NCIT_P375 "Irinotecan Sucrosofate" @default.
- NCIT_C82676 NCIT_P375 "Liposomal Irinotecan" @default.
- NCIT_C82676 NCIT_P399 "632436" @default.
- NCIT_C82676 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C82676 referenceCount "2" @default.
- NCIT_C82676 hasExactSynonym "IRINOTECAN SUCROSOFATE" @default.
- NCIT_C82676 hasExactSynonym "Irinotecan Liposome" @default.
- NCIT_C82676 hasExactSynonym "Irinotecan Sucrosofate" @default.
- NCIT_C82676 hasExactSynonym "MM 398" @default.
- NCIT_C82676 hasExactSynonym "MM-398" @default.
- NCIT_C82676 hasExactSynonym "MM398" @default.
- NCIT_C82676 hasExactSynonym "Nanoliposomal Irinotecan" @default.
- NCIT_C82676 hasExactSynonym "Nanoparticle Liposome Formulation of Irinotecan" @default.
- NCIT_C82676 hasExactSynonym "Onivyde" @default.
- NCIT_C82676 hasExactSynonym "PEP-02" @default.
- NCIT_C82676 hasExactSynonym "PEP02" @default.
- NCIT_C82676 hasExactSynonym "nal-IRI" @default.
- NCIT_C82676 inSubset NCIT_C116977 @default.
- NCIT_C82676 inSubset NCIT_C116978 @default.
- NCIT_C82676 inSubset NCIT_C128784 @default.
- NCIT_C82676 inSubset NCIT_C157711 @default.
- NCIT_C82676 inSubset NCIT_C157712 @default.
- NCIT_C82676 inSubset NCIT_C176424 @default.
- NCIT_C82676 inSubset NCIT_C177537 @default.
- NCIT_C82676 inSubset NCIT_C63923 @default.
- NCIT_C82676 type Class @default.
- NCIT_C82676 isDefinedBy ncit.owl @default.
- NCIT_C82676 label "Irinotecan Sucrosofate" @default.
- NCIT_C82676 subClassOf NCIT_C129824 @default.
- NCIT_C82676 subClassOf NCIT_C129825 @default.
- NCIT_C82676 subClassOf NCIT_C1748 @default.
- NCIT_C82676 subClassOf NCIT_C1904 @default.
- NCIT_C82676 subClassOf NCIT_C1908 @default.
- NCIT_C82676 subClassOf NCIT_C1909 @default.
- NCIT_C82676 subClassOf NCIT_C2189 @default.
- NCIT_C82676 subClassOf NCIT_C274 @default.
- NCIT_C82676 subClassOf NCIT_C2843 @default.
- NCIT_C82676 subClassOf NCIT_C471 @default.
- NCIT_C82676 subClassOf NCIT_C82676 @default.