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- NCIT_C82682 IAO_0000115 "Microporous hydrospheres of polyvinylalcohol (PVA) impregnated with irinotecan with potential antineoplastic activity. In transarterial chemoembolization (TACE), irinotecan-eluting beads are administered into blood vessels that feed the tumor, occluding tumor blood vessels and inducing ischemic tumor necrosis while simultaneously delivering high-dose chemotherapy locally. Irinotecan, a semisynthetic derivative of camptothecin, inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death." @default.
- NCIT_C82682 NCIT_A32 NCIT_C1909 @default.
- NCIT_C82682 NCIT_A7 NCIT_C16516 @default.
- NCIT_C82682 NCIT_NHC0 "C82682" @default.
- NCIT_C82682 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82682 NCIT_P107 "Irinotecan-Eluting Beads" @default.
- NCIT_C82682 NCIT_P108 "Irinotecan-Eluting Beads" @default.
- NCIT_C82682 NCIT_P208 "CL388467" @default.
- NCIT_C82682 NCIT_P322 "CTRP" @default.
- NCIT_C82682 NCIT_P322 "GDC" @default.
- NCIT_C82682 NCIT_P329 "632992" @default.
- NCIT_C82682 NCIT_P330 "632992" @default.
- NCIT_C82682 NCIT_P366 "Irinotecan-Eluting_Beads" @default.
- NCIT_C82682 NCIT_P375 "Irinotecan-Eluting Beads" @default.
- NCIT_C82682 NCIT_P399 "632992" @default.
- NCIT_C82682 normalizedInformationContent "100" @default.
- NCIT_C82682 referenceCount "1" @default.
- NCIT_C82682 hasExactSynonym "CM-BC2" @default.
- NCIT_C82682 hasExactSynonym "Irinotecan Hydrochloride Drug-eluting Beads" @default.
- NCIT_C82682 hasExactSynonym "Irinotecan-Eluting Beads" @default.
- NCIT_C82682 inSubset NCIT_C116977 @default.
- NCIT_C82682 inSubset NCIT_C116978 @default.
- NCIT_C82682 inSubset NCIT_C128784 @default.
- NCIT_C82682 inSubset NCIT_C157711 @default.
- NCIT_C82682 inSubset NCIT_C157712 @default.
- NCIT_C82682 inSubset NCIT_C176424 @default.
- NCIT_C82682 inSubset NCIT_C177537 @default.
- NCIT_C82682 type Class @default.
- NCIT_C82682 isDefinedBy ncit.owl @default.
- NCIT_C82682 label "Irinotecan-Eluting Beads" @default.
- NCIT_C82682 subClassOf NCIT_C129824 @default.
- NCIT_C82682 subClassOf NCIT_C129825 @default.
- NCIT_C82682 subClassOf NCIT_C1748 @default.
- NCIT_C82682 subClassOf NCIT_C1904 @default.
- NCIT_C82682 subClassOf NCIT_C1908 @default.
- NCIT_C82682 subClassOf NCIT_C1909 @default.
- NCIT_C82682 subClassOf NCIT_C2189 @default.
- NCIT_C82682 subClassOf NCIT_C274 @default.
- NCIT_C82682 subClassOf NCIT_C2843 @default.
- NCIT_C82682 subClassOf NCIT_C471 @default.
- NCIT_C82682 subClassOf NCIT_C82682 @default.