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- NCIT_C82683 IAO_0000115 "A humanized monoclonal antibody directed against insulin-like growth factors 1 and 2 (IGF-1/2) with potential antineoplastic activity. Dusigitumab inhibits IGF1- and IGF2-stimulated activation of membrane-bound IGF receptors and the subsequent triggering of proliferation and survival signaling pathways. This may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF1/2 ligands stimulate cell proliferation, enable oncogenic transformation, and suppress apoptosis; IGF1/2 signaling has been highly implicated in tumorigenesis and metastasis." @default.
- NCIT_C82683 NCIT_A32 NCIT_C1909 @default.
- NCIT_C82683 NCIT_A7 NCIT_C16743 @default.
- NCIT_C82683 NCIT_A7 NCIT_C16744 @default.
- NCIT_C82683 NCIT_NHC0 "C82683" @default.
- NCIT_C82683 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C82683 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C82683 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82683 NCIT_P107 "Dusigitumab" @default.
- NCIT_C82683 NCIT_P108 "Dusigitumab" @default.
- NCIT_C82683 NCIT_P207 "C2830209" @default.
- NCIT_C82683 NCIT_P210 "1204390-13-5" @default.
- NCIT_C82683 NCIT_P319 "0Z70DT5PRX" @default.
- NCIT_C82683 NCIT_P322 "CTRP" @default.
- NCIT_C82683 NCIT_P322 "FDA" @default.
- NCIT_C82683 NCIT_P322 "GDC" @default.
- NCIT_C82683 NCIT_P329 "633311" @default.
- NCIT_C82683 NCIT_P330 "633311" @default.
- NCIT_C82683 NCIT_P366 "Anti-IGF_1_2_Monoclonal_Antibody_MEDI-573" @default.
- NCIT_C82683 NCIT_P375 "Dusigitumab" @default.
- NCIT_C82683 NCIT_P399 "633311" @default.
- NCIT_C82683 NCIT_R124 NCIT_C17710 @default.
- NCIT_C82683 NCIT_R124 NCIT_C17828 @default.
- NCIT_C82683 NCIT_R124 NCIT_C18219 @default.
- NCIT_C82683 NCIT_R124 NCIT_C19986 @default.
- NCIT_C82683 NCIT_R124 NCIT_C40474 @default.
- NCIT_C82683 normalizedInformationContent "100" @default.
- NCIT_C82683 referenceCount "1" @default.
- NCIT_C82683 hasExactSynonym "Anti-Insulin-Like Growth Factor 1/2 Monoclonal Antibody MEDI-573" @default.
- NCIT_C82683 hasExactSynonym "DUSIGITUMAB" @default.
- NCIT_C82683 hasExactSynonym "Dusigitumab" @default.
- NCIT_C82683 hasExactSynonym "Immunoglobulin G2, Anti-(Human Insulin-like Growth Factor I/Insulin-like Growth Factor II); Human Monoclonal MEDI-573 gamma Heavy Chain (134-216')-Disulfide with Human Monoclonal MEDI-573 lambda Light Chain Dimer (222-222'':223-223'':226-226'':229-229'')-Tetrakisdisulfide" @default.
- NCIT_C82683 hasExactSynonym "MEDI-573" @default.
- NCIT_C82683 inSubset NCIT_C116977 @default.
- NCIT_C82683 inSubset NCIT_C116978 @default.
- NCIT_C82683 inSubset NCIT_C128784 @default.
- NCIT_C82683 inSubset NCIT_C157711 @default.
- NCIT_C82683 inSubset NCIT_C157712 @default.
- NCIT_C82683 inSubset NCIT_C176424 @default.
- NCIT_C82683 inSubset NCIT_C177537 @default.
- NCIT_C82683 inSubset NCIT_C63923 @default.
- NCIT_C82683 type Class @default.
- NCIT_C82683 isDefinedBy ncit.owl @default.
- NCIT_C82683 label "Dusigitumab" @default.
- NCIT_C82683 subClassOf NCIT_C129821 @default.
- NCIT_C82683 subClassOf NCIT_C129822 @default.
- NCIT_C82683 subClassOf NCIT_C1908 @default.
- NCIT_C82683 subClassOf NCIT_C1909 @default.
- NCIT_C82683 subClassOf NCIT_C20401 @default.
- NCIT_C82683 subClassOf NCIT_C274 @default.
- NCIT_C82683 subClassOf NCIT_C307 @default.
- NCIT_C82683 subClassOf NCIT_C308 @default.
- NCIT_C82683 subClassOf NCIT_C82683 @default.