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- NCIT_C82693 IAO_0000115 "The tosylate salt of rebastinib, an orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity. Rebastinib binds to and inhibits the Bcr-Abl fusion oncoprotein by changing the conformation of the folded protein to disallow ligand-dependent and ligand-independent activation; in addition, this agent binds to and inhibits Src family kinases LYN, HCK and FGR and the receptor tyrosine kinases TIE-2 and VEGFR-2. Rebastinib may exhibit more potent activity against T315I Bcr-Abl gatekeeper mutant kinases than other Bcr-Abl kinase inhibitors. The TIE-2 and VEGFR-2 receptor tyrosine kinases regulate angiogenesis, respectively, while the Src family kinases Abl, LYN, and HCK Src regulate a variety of cellular responses including differentiation, division, adhesion, and the stress response." @default.
- NCIT_C82693 NCIT_A32 NCIT_C1909 @default.
- NCIT_C82693 NCIT_A7 NCIT_C16325 @default.
- NCIT_C82693 NCIT_A7 NCIT_C17326 @default.
- NCIT_C82693 NCIT_A7 NCIT_C17483 @default.
- NCIT_C82693 NCIT_A7 NCIT_C18488 @default.
- NCIT_C82693 NCIT_A7 NCIT_C18558 @default.
- NCIT_C82693 NCIT_A7 NCIT_C28496 @default.
- NCIT_C82693 NCIT_NHC0 "C82693" @default.
- NCIT_C82693 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C82693 NCIT_P107 "Rebastinib Tosylate" @default.
- NCIT_C82693 NCIT_P108 "Rebastinib Tosylate" @default.
- NCIT_C82693 NCIT_P207 "C2830217" @default.
- NCIT_C82693 NCIT_P210 "1033893-29-6" @default.
- NCIT_C82693 NCIT_P319 "042A5NJE6B" @default.
- NCIT_C82693 NCIT_P322 "CTRP" @default.
- NCIT_C82693 NCIT_P322 "FDA" @default.
- NCIT_C82693 NCIT_P322 "GDC" @default.
- NCIT_C82693 NCIT_P329 "634547" @default.
- NCIT_C82693 NCIT_P330 "634547" @default.
- NCIT_C82693 NCIT_P350 "C30H28FN7O3.C7H8O3S" @default.
- NCIT_C82693 NCIT_P366 "Multitargeted_Tyrosine_Kinase_Inhibitor_DCC-2036" @default.
- NCIT_C82693 NCIT_P368 "CHEBI:62166" @default.
- NCIT_C82693 NCIT_P375 "Rebastinib Tosylate" @default.
- NCIT_C82693 NCIT_P399 "634547" @default.
- NCIT_C82693 normalizedInformationContent "100" @default.
- NCIT_C82693 referenceCount "1" @default.
- NCIT_C82693 hasExactSynonym "DCC-2036" @default.
- NCIT_C82693 hasExactSynonym "DP-1919.TO" @default.
- NCIT_C82693 hasExactSynonym "REBASTINIB TOSYLATE" @default.
- NCIT_C82693 hasExactSynonym "Rebastinib Tosylate" @default.
- NCIT_C82693 inSubset NCIT_C116977 @default.
- NCIT_C82693 inSubset NCIT_C116978 @default.
- NCIT_C82693 inSubset NCIT_C128784 @default.
- NCIT_C82693 inSubset NCIT_C157711 @default.
- NCIT_C82693 inSubset NCIT_C157712 @default.
- NCIT_C82693 inSubset NCIT_C176424 @default.
- NCIT_C82693 inSubset NCIT_C177537 @default.
- NCIT_C82693 inSubset NCIT_C63923 @default.
- NCIT_C82693 type Class @default.
- NCIT_C82693 isDefinedBy ncit.owl @default.
- NCIT_C82693 label "Rebastinib Tosylate" @default.
- NCIT_C82693 subClassOf NCIT_C129824 @default.
- NCIT_C82693 subClassOf NCIT_C129825 @default.
- NCIT_C82693 subClassOf NCIT_C1404 @default.
- NCIT_C82693 subClassOf NCIT_C1908 @default.
- NCIT_C82693 subClassOf NCIT_C1909 @default.
- NCIT_C82693 subClassOf NCIT_C1967 @default.
- NCIT_C82693 subClassOf NCIT_C2189 @default.
- NCIT_C82693 subClassOf NCIT_C274 @default.
- NCIT_C82693 subClassOf NCIT_C471 @default.
- NCIT_C82693 subClassOf NCIT_C82693 @default.