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- NCIT_C83552 IAO_0000115 "A 4'-O-benzylated analogue of the anthracycline derivative doxorubicin, with potential antineoplastic activity. Berubicin intercalates into DNA and interrupts topoisomerase II activity, resulting in the inhibition of DNA replication and repair, as well as RNA and protein synthesis. Unlike other anthracycline derivatives, this agent crosses the blood-brain barrier (BBB) and can circumvent P glycoprotein/MRP1-mediated efflux." @default.
- NCIT_C83552 NCIT_A5 NCIT_C61568 @default.
- NCIT_C83552 NCIT_NHC0 "C83552" @default.
- NCIT_C83552 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C83552 NCIT_P108 "Berubicin" @default.
- NCIT_C83552 NCIT_P207 "C2827086" @default.
- NCIT_C83552 NCIT_P210 "677017-23-1" @default.
- NCIT_C83552 NCIT_P319 "6QPN83HK2M" @default.
- NCIT_C83552 NCIT_P322 "FDA" @default.
- NCIT_C83552 NCIT_P350 "C34H35NO11" @default.
- NCIT_C83552 normalizedInformationContent "100" @default.
- NCIT_C83552 referenceCount "1" @default.
- NCIT_C83552 hasExactSynonym "(8S,10S)-10-((3-Amino-4-O-Benzyl-2,3,6-Trideoxy-A-L-Lyxo-Hexopyranosyl)Oxy)-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxy-7,8,9,10-Tetrahydrotetracene-5,12-Dione" @default.
- NCIT_C83552 hasExactSynonym "5,12-Naphthacenedione, 10-((3-Amino-2,3,6-Trideoxy-4-O-(Phenylmethyl)-Alpha-L-Lyxo-Hexopyranosyl)Oxy)-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(Hydroxyacetyl)-1-Methoxy-, (8S,10S)-" @default.
- NCIT_C83552 hasExactSynonym "BERUBICIN" @default.
- NCIT_C83552 hasExactSynonym "Berubicin" @default.
- NCIT_C83552 inSubset NCIT_C63923 @default.
- NCIT_C83552 type Class @default.
- NCIT_C83552 isDefinedBy ncit.owl @default.
- NCIT_C83552 label "Berubicin" @default.
- NCIT_C83552 subClassOf NCIT_C129824 @default.
- NCIT_C83552 subClassOf NCIT_C129825 @default.
- NCIT_C83552 subClassOf NCIT_C1594 @default.
- NCIT_C83552 subClassOf NCIT_C1748 @default.
- NCIT_C83552 subClassOf NCIT_C186664 @default.
- NCIT_C83552 subClassOf NCIT_C1908 @default.
- NCIT_C83552 subClassOf NCIT_C1909 @default.
- NCIT_C83552 subClassOf NCIT_C1968 @default.
- NCIT_C83552 subClassOf NCIT_C2115 @default.
- NCIT_C83552 subClassOf NCIT_C2161 @default.
- NCIT_C83552 subClassOf NCIT_C2189 @default.
- NCIT_C83552 subClassOf NCIT_C259 @default.
- NCIT_C83552 subClassOf NCIT_C274 @default.
- NCIT_C83552 subClassOf NCIT_C2842 @default.
- NCIT_C83552 subClassOf NCIT_C471 @default.
- NCIT_C83552 subClassOf NCIT_C83552 @default.