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- NCIT_C83554 IAO_0000115 "A histamine analog with weak histamine H1 agonistic and more potent histamine H3 antagonistic properties. Upon intranasal administration, betahistine binds to histamine H1 and H3 receptors and exerts its agonistic and antagonistic actions locally and centrally. This promotes cochlear, vestibular and cerebral blood flow, decreases neuronal firing in the vestibular nuclei and increases histamine synthesis and release in the brain which facilitates vestibular compensation. Increased blood flow around the inner ear reduces the amount of fluid in the inner ear and may alleviate vertigo, tinnitus, and hearing loss." @default.
- NCIT_C83554 NCIT_A5 NCIT_C73794 @default.
- NCIT_C83554 NCIT_NHC0 "C83554" @default.
- NCIT_C83554 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C83554 NCIT_P108 "Betahistine" @default.
- NCIT_C83554 NCIT_P207 "C0005301" @default.
- NCIT_C83554 NCIT_P210 "5638-76-6" @default.
- NCIT_C83554 NCIT_P319 "X32KK4201D" @default.
- NCIT_C83554 NCIT_P322 "FDA" @default.
- NCIT_C83554 NCIT_P350 "C8H12N2" @default.
- NCIT_C83554 NCIT_P368 "CHEBI:35677" @default.
- NCIT_C83554 normalizedInformationContent "100" @default.
- NCIT_C83554 referenceCount "1" @default.
- NCIT_C83554 hasExactSynonym "BETAHISTINE" @default.
- NCIT_C83554 hasExactSynonym "Betahistine" @default.
- NCIT_C83554 inSubset NCIT_C63923 @default.
- NCIT_C83554 type Class @default.
- NCIT_C83554 isDefinedBy ncit.owl @default.
- NCIT_C83554 label "Betahistine" @default.
- NCIT_C83554 subClassOf NCIT_C1908 @default.
- NCIT_C83554 subClassOf NCIT_C1909 @default.
- NCIT_C83554 subClassOf NCIT_C29707 @default.
- NCIT_C83554 subClassOf NCIT_C78274 @default.
- NCIT_C83554 subClassOf NCIT_C83554 @default.