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- NCIT_C83721 IAO_0000115 "The tromethamine salt form of prodrug fosbretabulin, a water-soluble phosphate derivative of a stilbenoid phenol derived from the African bush willow (Combretum caffrum) with antineoplastic activities. Upon administration, fosbretabulin is dephosphorylated to its active metabolite, combretastatin A4, which targets and binds to tubulin dimers and prevents microtubule polymerization, thereby resulting in mitotic arrest and apoptosis in endothelial cells. As apoptotic endothelial cells detach from their substrata, tumor blood vessels collapse; the acute disruption of tumor blood flow may result in tumor necrosis." @default.
- NCIT_C83721 NCIT_A32 NCIT_C1909 @default.
- NCIT_C83721 NCIT_A6 NCIT_C82378 @default.
- NCIT_C83721 NCIT_A7 NCIT_C17219 @default.
- NCIT_C83721 NCIT_NHC0 "C83721" @default.
- NCIT_C83721 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C83721 NCIT_P107 "Fosbretabulin Tromethamine" @default.
- NCIT_C83721 NCIT_P108 "Fosbretabulin Tromethamine" @default.
- NCIT_C83721 NCIT_P207 "C2827157" @default.
- NCIT_C83721 NCIT_P210 "404886-32-4" @default.
- NCIT_C83721 NCIT_P319 "GBW044919E" @default.
- NCIT_C83721 NCIT_P322 "CTRP" @default.
- NCIT_C83721 NCIT_P322 "FDA" @default.
- NCIT_C83721 NCIT_P322 "GDC" @default.
- NCIT_C83721 NCIT_P329 "696306" @default.
- NCIT_C83721 NCIT_P330 "696306" @default.
- NCIT_C83721 NCIT_P350 "C18H21O8P.C4H11NO3" @default.
- NCIT_C83721 NCIT_P375 "Fosbretabulin Tromethamine" @default.
- NCIT_C83721 NCIT_P399 "696306" @default.
- NCIT_C83721 NCIT_R124 NCIT_C17828 @default.
- NCIT_C83721 NCIT_R124 NCIT_C20480 @default.
- NCIT_C83721 NCIT_R124 NCIT_C40795 @default.
- NCIT_C83721 NCIT_R124 NCIT_C40798 @default.
- NCIT_C83721 normalizedInformationContent "100" @default.
- NCIT_C83721 referenceCount "1" @default.
- NCIT_C83721 hasExactSynonym "1,3-Dihydroxy-2-(Hydroxymethyl)Propan-2-Aminium 2-Methoxy-5-((1z)-2-(3,4,5-Trimethoxyphenyl)Ethenyl)Phenyl Hydrogen Phosphate" @default.
- NCIT_C83721 hasExactSynonym "1,3-Propanediol, 2-Amino-2-(Hydroxymethyl)-, Compd. With 2-Methoxy-5-((1z)-2-(3,4,5-Trimethoxyphenyl)Ethenyl)Phenyl Dihydrogen Phosphate (1:1)" @default.
- NCIT_C83721 hasExactSynonym "CA4P" @default.
- NCIT_C83721 hasExactSynonym "FOSBRETABULIN TROMETHAMINE" @default.
- NCIT_C83721 hasExactSynonym "Fosbretabulin Tromethamine" @default.
- NCIT_C83721 hasExactSynonym "Zybrestat" @default.
- NCIT_C83721 inSubset NCIT_C116977 @default.
- NCIT_C83721 inSubset NCIT_C116978 @default.
- NCIT_C83721 inSubset NCIT_C128784 @default.
- NCIT_C83721 inSubset NCIT_C157711 @default.
- NCIT_C83721 inSubset NCIT_C157712 @default.
- NCIT_C83721 inSubset NCIT_C176424 @default.
- NCIT_C83721 inSubset NCIT_C177537 @default.
- NCIT_C83721 inSubset NCIT_C63923 @default.
- NCIT_C83721 type Class @default.
- NCIT_C83721 isDefinedBy ncit.owl @default.
- NCIT_C83721 label "Fosbretabulin Tromethamine" @default.
- NCIT_C83721 subClassOf NCIT_C186664 @default.
- NCIT_C83721 subClassOf NCIT_C1908 @default.
- NCIT_C83721 subClassOf NCIT_C1909 @default.
- NCIT_C83721 subClassOf NCIT_C25974 @default.
- NCIT_C83721 subClassOf NCIT_C273 @default.
- NCIT_C83721 subClassOf NCIT_C274 @default.
- NCIT_C83721 subClassOf NCIT_C67421 @default.
- NCIT_C83721 subClassOf NCIT_C83721 @default.