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- NCIT_C845 IAO_0000115 "A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Unlike other nitrosoureas, streptozocin causes little myelosuppression. (NCI04)" @default.
- NCIT_C845 NCIT_A32 NCIT_C1909 @default.
- NCIT_C845 NCIT_NHC0 "C845" @default.
- NCIT_C845 NCIT_P106 "Antibiotic" @default.
- NCIT_C845 NCIT_P106 "Organic Chemical" @default.
- NCIT_C845 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C845 NCIT_P108 "Streptozocin" @default.
- NCIT_C845 NCIT_P175 "85998" @default.
- NCIT_C845 NCIT_P207 "C0038432" @default.
- NCIT_C845 NCIT_P210 "18883-66-4" @default.
- NCIT_C845 NCIT_P302 "Carcinoid tumor and syndrome; Colorectal cancer, palliative; Hodgkin's disease; Metastatic islet cell carcinoma of the pancreas" @default.
- NCIT_C845 NCIT_P319 "5W494URQ81" @default.
- NCIT_C845 NCIT_P322 "FDA" @default.
- NCIT_C845 NCIT_P322 "GDC" @default.
- NCIT_C845 NCIT_P325 "An anticancer drug that belongs to the family of drugs called alkylating agents." @default.
- NCIT_C845 NCIT_P329 "42831" @default.
- NCIT_C845 NCIT_P330 "42831" @default.
- NCIT_C845 NCIT_P350 "C8H15N3O7" @default.
- NCIT_C845 NCIT_P366 "Streptozocin" @default.
- NCIT_C845 NCIT_P368 "CHEBI:9288" @default.
- NCIT_C845 NCIT_P375 "Streptozocin" @default.
- NCIT_C845 NCIT_P399 "42831" @default.
- NCIT_C845 normalizedInformationContent "80.873941456936294" @default.
- NCIT_C845 referenceCount "18" @default.
- NCIT_C845 hasExactSynonym "2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose" @default.
- NCIT_C845 hasExactSynonym "2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose" @default.
- NCIT_C845 hasExactSynonym "2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose" @default.
- NCIT_C845 hasExactSynonym "STREPTOZOCIN" @default.
- NCIT_C845 hasExactSynonym "STZ" @default.
- NCIT_C845 hasExactSynonym "Streptozocin" @default.
- NCIT_C845 hasExactSynonym "Streptozotocin" @default.
- NCIT_C845 hasExactSynonym "U 9889" @default.
- NCIT_C845 hasExactSynonym "U-9889" @default.
- NCIT_C845 hasExactSynonym "Zanosar" @default.
- NCIT_C845 hasExactSynonym "streptozocin" @default.
- NCIT_C845 inSubset NCIT_C128784 @default.
- NCIT_C845 inSubset NCIT_C157711 @default.
- NCIT_C845 inSubset NCIT_C157712 @default.
- NCIT_C845 inSubset NCIT_C176424 @default.
- NCIT_C845 inSubset NCIT_C177537 @default.
- NCIT_C845 inSubset NCIT_C63923 @default.
- NCIT_C845 type Class @default.
- NCIT_C845 isDefinedBy ncit.owl @default.
- NCIT_C845 label "Streptozocin" @default.
- NCIT_C845 subClassOf NCIT_C1590 @default.
- NCIT_C845 subClassOf NCIT_C186664 @default.
- NCIT_C845 subClassOf NCIT_C1908 @default.
- NCIT_C845 subClassOf NCIT_C1909 @default.
- NCIT_C845 subClassOf NCIT_C274 @default.
- NCIT_C845 subClassOf NCIT_C2842 @default.
- NCIT_C845 subClassOf NCIT_C699 @default.
- NCIT_C845 subClassOf NCIT_C845 @default.