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- NCIT_C84511 IAO_0000115 "The sodium salt of imetelstat, a synthetic lipid-conjugated, 13-mer oligonucleotide N3' P5'-thio-phosphoramidate with potential antineoplastic activity. Complementary to the template region of telomerase RNA (hTR), imetelstat acts as a competitive enzyme inhibitor that binds and blocks the active site of the enzyme (a "telomerase template antagonist"), a mechanism of action which differs from that for the antisense oligonucleotide-mediated inhibition of telomerase activity through telomerase mRNA binding. Inhibition of telomerase activity in tumor cells by imetelstat results in telomere shortening, which leads to cell cycle arrest or apoptosis." @default.
- NCIT_C84511 NCIT_A32 NCIT_C1909 @default.
- NCIT_C84511 NCIT_A6 NCIT_C49084 @default.
- NCIT_C84511 NCIT_A7 NCIT_C17470 @default.
- NCIT_C84511 NCIT_NHC0 "C84511" @default.
- NCIT_C84511 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C84511 NCIT_P107 "Imetelstat Sodium" @default.
- NCIT_C84511 NCIT_P108 "Imetelstat Sodium" @default.
- NCIT_C84511 NCIT_P207 "C1708156" @default.
- NCIT_C84511 NCIT_P210 "1007380-31-5" @default.
- NCIT_C84511 NCIT_P319 "2AW48LAZ4I" @default.
- NCIT_C84511 NCIT_P322 "CTRP" @default.
- NCIT_C84511 NCIT_P322 "FDA" @default.
- NCIT_C84511 NCIT_P322 "GDC" @default.
- NCIT_C84511 NCIT_P329 "447136" @default.
- NCIT_C84511 NCIT_P330 "447136" @default.
- NCIT_C84511 NCIT_P350 "C148H198N68O53P13S13.13Na" @default.
- NCIT_C84511 NCIT_P375 "Imetelstat Sodium" @default.
- NCIT_C84511 NCIT_P399 "447136" @default.
- NCIT_C84511 normalizedInformationContent "100" @default.
- NCIT_C84511 referenceCount "1" @default.
- NCIT_C84511 hasExactSynonym "DNA, d(3'-amino-3'-deoxy-P-thio)(T-A-G-G-G-T-T-A-G-A-C-A-A), 5'-[O-[2-hydroxy-3- [(1-oxohexadecyl)amino]propyl] hydrogen phosphorothioate], Sodium Salt (1:13)" @default.
- NCIT_C84511 hasExactSynonym "GRN163L" @default.
- NCIT_C84511 hasExactSynonym "GRN163L, Sodium Salt" @default.
- NCIT_C84511 hasExactSynonym "IMETELSTAT SODIUM" @default.
- NCIT_C84511 hasExactSynonym "Imetelstat Sodium" @default.
- NCIT_C84511 inSubset NCIT_C116977 @default.
- NCIT_C84511 inSubset NCIT_C116978 @default.
- NCIT_C84511 inSubset NCIT_C128784 @default.
- NCIT_C84511 inSubset NCIT_C157711 @default.
- NCIT_C84511 inSubset NCIT_C157712 @default.
- NCIT_C84511 inSubset NCIT_C176424 @default.
- NCIT_C84511 inSubset NCIT_C177537 @default.
- NCIT_C84511 inSubset NCIT_C63923 @default.
- NCIT_C84511 type Class @default.
- NCIT_C84511 isDefinedBy ncit.owl @default.
- NCIT_C84511 label "Imetelstat Sodium" @default.
- NCIT_C84511 subClassOf NCIT_C1291 @default.
- NCIT_C84511 subClassOf NCIT_C1908 @default.
- NCIT_C84511 subClassOf NCIT_C1909 @default.
- NCIT_C84511 subClassOf NCIT_C1962 @default.
- NCIT_C84511 subClassOf NCIT_C2826 @default.
- NCIT_C84511 subClassOf NCIT_C307 @default.
- NCIT_C84511 subClassOf NCIT_C471 @default.
- NCIT_C84511 subClassOf NCIT_C84511 @default.